Phenolic and iridoid glycosides from the rhizomes of Cyperus rotundus L.
Phenolic and iridoid glycosides from the rhizomes of Cyperus rotundus L.
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DOI：
10.1007/s00044-013-0504-9
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发表时间：
2013-01
影响因子：
2.6
通讯作者：
Zhong-liu Zhou;Hua-lin Zhang
中科院分区：
文献类型：
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作者：
Zhong-liu Zhou;Hua-lin Zhang
从香附子根茎中分离出两种新的环烯醚萜苷类化合物，即 rotunduside A (1) 和 rotunduside B (2)，以及四种已知化合物：6′′-O-p-coumaroylgenipin 龙胆二糖苷 (3)、isoaragoside (4)、chionoside A (5) 和 helioside C (6)。它们的化学结构是通过应用光谱（NMR、MS）和化学方法确定的。报告了所有分离化合物的巨噬细胞呼吸爆发（MRB）抑制活性。测试中，化合物 2 对 MRB 显示出边际抑制活性，IC50 值约为 31 μM。
Two new iridoid glycosides, rotunduside A (1) and rotunduside B (2), along with four known compounds, 6′′-O-p-coumaroylgenipin gentiobioside (3), isoaragoside (4), chionoside A (5), and helioside C (6) were isolated from the rhizomes ofCyperus rotundusL. Their chemical structures were determined by application of spectroscopic (NMR, MS) and chemical methodologies. The macrophages respiratory burst (MRB) inhibitory activity of all the isolated compounds was reported. Compound2showed marginal inhibitory activity against MRB in the test with IC50value of approximately 31 μM.