Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia
Post-acute COVID-19 associated with evidence of bystander T-cell activation and a recurring antibiotic-resistant bacterial pneumonia
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急性后 COVID-19 与旁观者 T 细胞激活和反复出现的抗生素耐药性细菌性肺炎相关
DOI：
10.1101/2020.09.17.20190033
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Gregorova M
中科院分区：
文献类型：
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作者：
Gregorova M
在这里，我们描述了一例COVID-19患者，该患者发生了由铜绿假单胞菌引起的复发性呼吸机相关性肺炎，治疗后获得了越来越高的抗菌素耐药性（AMR）。宏基因组分析揭示了AMR基因型，而免疫学分析揭示了大量和不断升级的T细胞活化水平。这两种病毒均为SARS-CoV-2和P.空气动力学特异性和旁观者激活，这可能导致该患者的持续症状和放射学变化。
Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused byPseudomonas aeruginosathat acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 andP. aeruginosaspecific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.