Hypoxic control of metastasis.
Hypoxic control of metastasis.
复制标题
转移的缺氧控制。
DOI：
10.1126/science.aaf4405
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发表时间：
2016-04-08
期刊：
影响因子：
--
通讯作者：
Giaccia AJ
中科院分区：
文献类型：
--
作者：
Rankin EB;Giaccia AJ
转移性疾病是癌症相关死亡的主要原因，涉及肿瘤细胞和微环境之间的关键相互作用。缺氧是促进转移进展的有效微环境因素。临床上，缺氧和缺氧诱导的转录因子HIF-1和HIF-2的表达与多种肿瘤类型的远处转移增加和生存率差相关。此外，恶性细胞中的HIF信号传导影响转移级联中的多个步骤。在这里，我们审查的研究重点是阐明缺氧肿瘤微环境促进转移进展的机制。这些研究已经确定了由缺氧调节的潜在生物标志物和治疗靶点，可以将其纳入旨在预防和治疗转移性疾病的策略中。
Metastatic disease is the leading cause of cancer-related deaths and involves critical interactions between tumor cells and the microenvironment. Hypoxia is a potent microenvironmental factor promoting metastatic progression. Clinically, hypoxia and the expression of the hypoxia-inducible transcription factors HIF-1 and HIF-2 are associated with increased distant metastasis and poor survival in a variety of tumor types. Moreover, HIF signaling in malignant cells influences multiple steps within the metastatic cascade. Here we review research focused on elucidating the mechanisms by which the hypoxic tumor microenvironment promotes metastatic progression. These studies have identified potential biomarkers and therapeutic targets regulated by hypoxia that could be incorporated into strategies aimed at preventing and treating metastatic disease.