Dynamic modulation of decision biases by brainstem arousal systems
Dynamic modulation of decision biases by brainstem arousal systems
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DOI：
10.7554/elife.23232
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发表时间：
2017-04-11
期刊：
影响因子：
7.7
通讯作者：
Donner, Tobias H.
中科院分区：
文献类型：
--
作者：
de Gee, Jan Willem;Colizoli, Olympic;Donner, Tobias H.
当面对相同证据的反复呈现时，决策者往往会做出不同的选择。行为的可变性通常归因于大脑决策机制中的噪音。我们假设脑干觉醒系统的相位反应是这种可变性的重要来源。我们在不同的感觉模式和任务协议中跟踪了人类在感觉-运动决策过程中的瞳孔反应（相位唤醒的代理）。大瞳孔反应通常预示着决策偏差的减少。通过功能磁共振成像，我们发现瞳孔相关的偏置减少(i)伴随着顶叶和前额叶皮层中选择编码模式信号的调节，（ii）通过一些参与皮层唤醒状态控制的神经调节脑干中心（包括去肾上腺素能蓝斑）的相位，瞳孔相关的反应来预测。我们得出的结论是，在一个又一个试验的基础上，相位唤醒抑制了决策偏差，从而解释了选择行为可变性的一个重要组成部分。
Decision-makers often arrive at different choices when faced with repeated presentations of the same evidence. Variability of behavior is commonly attributed to noise in the brains decision-making machinery. We hypothesized that phasic responses of brainstem arousal systems are a significant source of this variability. We tracked pupil responses (a proxy of phasic arousal) during sensory-motor decisions in humans, across different sensory modalities and task protocols. Large pupil responses generally predicted a reduction in decision bias. Using fMRI, we showed that the pupil-linked bias reduction was (i) accompanied by a modulation of choice-encoding pattern signals in parietal and prefrontal cortex and (ii) predicted by phasic, pupil-linked responses of a number of neuromodulatory brainstem centers involved in the control of cortical arousal state, including the noradrenergic locus coeruleus. We conclude that phasic arousal suppresses decision bias on a trial-by-trial basis, thus accounting for a significant component of the variability of choice behavior.