The effect of continuous passive motion on the clearance of a hemarthrosis from a synovial joint. An experimental investigation in the rabbit.
The effect of continuous passive motion on the clearance of a hemarthrosis from a synovial joint. An experimental investigation in the rabbit.
复制标题
连续被动运动对滑膜关节积血清除的影响。
DOI：
10.1097/00003086-198306000-00044
复制
发表时间：
1983
影响因子：
4.2
通讯作者：
R. Salter
中科院分区：
文献类型：
--
作者：
S. O’Driscoll;A. Kumar;R. Salter
在16只青春期新西兰兔（体重2.1 - 2.3kg）上研究了持续被动运动（CPM）对膝关节和滑膜血液清除的影响。将2ml用铟-111-oxine标记并在生理盐水中重建的自体抗凝红细胞注射到7只家兔的双膝中。在左后肢处于石膏中的情况下，在第0、1、2、3、4和7天使用准直伽马照相机对每个膝关节进行定量扫描。在整个实验过程中，每只兔子的左膝关节被固定，右膝关节从40%到110%的屈曲连续移动，除了在扫描期间。第7天扫描后，处死家兔，从膝关节解剖所有组织，使关节囊保持完整。完整的膝盖被从身体中取出并扫描。对关节进行切开、冲洗和重新扫描。滑膜切片进行组织学检查。另外九只兔子用未标记的血液进行相同的处理，并在一到七天后杀死进行大体检查。三天后，CPM膝关节中没有血液，但一些石膏膝关节在七天后仍然含有血液。CPM的清除率比石膏固定快两倍多（t %= 2.2 vs t %= 5.5天; p <0.001）。CPM固定7天后，滑膜中残留的血液明显少于石膏固定（7.1%对13.2%; p <0.01）。组织学检查显示CPM对红细胞的捕获较少。标记的红细胞在体循环中游离。
The effect of continuous passive motion (CPM) on the clearance of blood from the knee joint and synovium was studied in 16 adolescent New Zealand rabbits (weight, 2.1–2.3 kg). Two milliliters of autologous anticoagulated erythrocytes that had been labelled with indium-111-oxine and reconstituted in normal saline were injected into both knees in seven rabbits. With the left hind limb in a cast, quantitative scanning of each knee was performed on days 0, 1, 2, 3, 4, and 7 using a collimated gamma camera. Throughout the experiment the left knee joint of each rabbit was immobilized, and the right knee joint was moved continuously from 40% to 110% of flexion, except during the scans. After the day 7 scan, the rabbits were killed and all tissues dissected from the knees, leaving the capsules intact. The intact knees were removed from the body and scanned. The joints were incised, irrigated, and rescanned. Sections of synovium were examined histologically. Nine additional rabbits were treated identically with unlabelled blood and killed one to seven days later for gross inspection. After three days there was no blood in the CPM knees, but some of the cast knees still contained blood after seven days. The rate of clearance was more than twice as fast with CPM than with cast immobilization (t%= 2.2 versus t%= 5.5 days; p< 0.001). Significantly less blood remained in the synovium after seven days with CPM than with cast immobilization (7.1% versus 13.2%; p< 0.01). Histologic examination showed less trapping of erythrocytes with CPM. Labelled erythrocytes were demonstrated free in the systemic circulation.