Association of Adolescent- and Caregiver-Reported Antiretroviral Therapy Adherence with HIV Viral Load Among Perinatally-infected South African Adolescents.
Association of Adolescent- and Caregiver-Reported Antiretroviral Therapy Adherence with HIV Viral Load Among Perinatally-infected South African Adolescents.
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DOI：
10.1007/s10461-017-2004-2
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发表时间：
2018-03
影响因子：
4.4
通讯作者：
Myer L
中科院分区：
文献类型：
--
作者：
Brittain K;Asafu-Agyei NA;Hoare J;Bekker LG;Rabie H;Nuttall J;Roux P;Stein DJ;Zar HJ;Myer L
准确衡量抗逆转录病毒治疗(ART)的依从性仍然具有挑战性，而且几乎没有数据评估围产期感染艾滋病毒的青少年自我报告的依从性。我们检查了南非开普敦9-14岁围产期感染青少年中青少年和照顾者关于青少年依从性的报告，并探索了可能改变报告的依从性和病毒载量(VL)升高之间的关联的因素。在474名青少年(中位年龄：12.0岁；使用ART的中位持续时间：7.5年)中，VL升高和照顾者-以及青少年-报告错过ART剂量的情况很常见。VL升高在年龄较大的男性青少年中尤其普遍。在照顾者和青少年报告之间观察到低-中等的一致性。在≥12岁的青少年中，照顾者和青少年报告的依从性与大多数评估项目中VL的升高有关，但在12岁的青少年中几乎没有观察到显著的相关性。在这方面，需要改进遵守措施和工具，以确定需要遵守干预措施的青少年。
Accurate measurement of antiretroviral therapy (ART) adherence remains challenging and there are few data assessing the validity of self-reported adherence among perinatally HIV-infected adolescents. We examined adolescent and caregiver reports of adolescent adherence among perinatally-infected adolescents aged 9-14 years in Cape Town, South Africa, and explored factors that may modify associations between reported adherence and elevated viral load (VL). Among 474 adolescents (median age: 12.0 years; median duration of ART use: 7.5 years), elevated VL and caregiver- and adolescent-report of missed ART doses were common. Elevated VL was particularly prevalent among older, male adolescents. Low-moderate concordance was observed between caregiver and adolescent report. Among adolescents aged ≥12 years, caregiver- and adolescent-reported adherence was associated with elevated VL across most items assessed, but few significant associations were observed among adolescents <12 years of age. Refined adherence measures and tools to identify adolescents who require adherence interventions are needed in this context.
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影响因子：
1.7
作者：
Bhana A;Mellins CA;Petersen I;Alicea S;Myeza N;Holst H;Abrams E;John S;Chhagan M;Nestadt DF;Leu CS;McKay M
通讯作者：
McKay M
影响因子：
4.6
作者：
Wilson, Ira B;Carter, Amanda E;Berg, Karina M
通讯作者：
Berg, Karina M
影响因子：
2.1
作者：
Koenig, Linda J.;Nesheim, Steven;Abramowitz, Susan
通讯作者：
Abramowitz, Susan
影响因子：
3.6
作者：
Martin, Staci;Elliott-DeSorbo, Deborah K.;Wood, Lauren V.
通讯作者：
Wood, Lauren V.
影响因子：
3.6
作者：
Mellins, CA;Brackis-Cott, E;Abrams, EJ
通讯作者：
Abrams, EJ