Feasibility of T2 Mapping and Magnetic Transfer Ratio for Diagnosis of Intervertebral Disc Degeneration at the Cervicothoracic Junction: A Pilot Study
Feasibility of T2 Mapping and Magnetic Transfer Ratio for Diagnosis of Intervertebral Disc Degeneration at the Cervicothoracic Junction: A Pilot Study
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T2 映射和磁传输比诊断颈胸交界处椎间盘退变的可行性：初步研究
DOI：
10.1155/2019/6396073
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发表时间：
2019-01-01
影响因子：
--
通讯作者：
Chen, Chun
中科院分区：
文献类型：
--
作者：
Zhang, Chao;Lin, Yuan;Chen, Chun
研究背景脊柱颈胸段椎间盘退变（IDD）在临床上具有重要意义，但目前尚缺乏足够的重视。T2标测和磁转移率（MTR）是有用的磁共振成像（MRI）技术来定量评估IDD，揭示椎间盘内的生化变化。为了比较T2标测与MTR成像定量诊断颈胸交界处椎间盘退变的准确性，评价了解剖水平、性别、年龄和T2弛豫时间值和MTR值的Pfirrmann分级的影响。方法对67例颈部及上腰痛患者行T2标测和MTR成像。测量C7和T3之间每个椎间盘的Pfirrmann分级、T2弛豫时间值和MTR值。不同的节段水平，性别，年龄范围和Pfirrmann等级之间的差异进行了研究。使用受试者工作特征（ROC）曲线比较两种MRI技术的诊断准确性。结果T2弛豫时间和MTR值在不同解剖水平、不同性别、不同节段之间差异无统计学意义。随着年龄的增长，T2弛豫时间值逐渐减小，MTR值逐渐增大。重要的是，我们证明了T2弛豫时间值或MTR值与Pfirrmann分级之间的显著相关性。结论T2标测对颈胸段椎间盘退变的定量评价准确性优于MTR成像。
Background Intervertebral disc degeneration (IDD) at the cervicothoracic junction of spine is clinically relevant, however, little attention had been paid. T2 mapping and magnetic transfer ratio (MTR) are useful magnetic resonance imaging (MRI) techniques to quantitatively evaluate IDD, revealing the biochemical changes within the intervertebral disc. To compare T2 mapping with MTR imaging regarding their accuracy to quantitatively diagnose intervertebral disc degeneration at the cervicothoracic junction, influences of anatomical level, gender, age, and Pfirrmann grade of T2 relaxation time values and MTR values were evaluated. Methods Sixty-seven patients with neck and upper back pain were included and examined with both T2 mapping and MTR imaging. The Pfirrmann grade, T2 relaxation time values, and MTR value of each disc between C7 and T3 were measured. Differences were investigated among different segmental levels, genders, age ranges, and Pfirrmann grades. The diagnostic accuracy of both MRI techniques was compared using the receiver operating characteristic (ROC) curves. Results No significant difference was detected comparing T2 relaxation time values or MTR values among different anatomical levels, genders, and segmental levels. And we generally found that T2 relaxation time values decreased, while MTR value increased with increasing age. Importantly, we demonstrated the significant correlation between either T2 relaxation time values or MTR value and Pfirrmann grade. Conclusion We proved the better accuracy of T2 mapping over MTR imaging to quantitatively evaluate the intervertebral disc degeneration of the cervicothoracic junction.