A nod and a Wnk to axon branching and destruction.

A nod and a Wnk to axon branching and destruction.
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对轴突分支和破坏的点头和Wnk。

DOI:
10.1016/j.neuron.2021.08.027
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发表时间:
2021
期刊:
影响因子:
16.2
通讯作者:
Peters OM
Peters OM
中科院分区:
医学1区
文献类型:
--
作者:
Peters OM

文献摘要

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在本期《神经元》杂志中,Izadifar et al.(2021)已经鉴定了一种保守分子Wnk作为神经元发育轴突分支和长期存活的关键调节因子,表征了其与包括Sarm在内的轴突破坏基因的相互作用。Wnk的发现对于我们理解神经发育和神经退行性疾病具有重要意义。
In this issue ofNeuron, Izadifar et al. (2021) have identified a conserved molecule Wnk as a key regulator in both developmental axon branching and long-term survival of neurons, characterizing its interplay with axon destruction genes including Sarm. The discovery of Wnk will be important to our understanding of neurodevelopmental and neurodegenerative diseases.