Interaction of a Golgi-associated kinesin-like protein with Rab6
Interaction of a Golgi-associated kinesin-like protein with Rab6
复制标题
DOI：
10.1126/science.279.5350.580
复制
发表时间：
1998-01-23
期刊：
影响因子：
56.9
通讯作者：
Goud, B
中科院分区：
文献类型：
--
作者：
Echard, A;Jollivet, F;Goud, B
鸟苷三磷酸酶调节真核细胞内囊泡运输和膜运输。在这里，一个驱动蛋白样蛋白，与鸟苷三磷酸（GTP）结合形式的Rab 6相互作用被确定。这种蛋白质，称为Rabkinesin-6，被定位于高尔基体，并显示在这个细胞器的动力学中发挥作用。Rabkinesin-6的羧基端结构域包含Rab 6相互作用结构域，抑制Rab 6-GTP对细胞内转运的作用，因此，分子马达是Rab蛋白的潜在效应器，这两个蛋白家族成员之间的协调作用可以控制膜动力学和定向囊泡运输。
Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport, Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.