Serotonin receptors induced by exogenous messenger RNA in Xenopus oocytes
Serotonin receptors induced by exogenous messenger RNA in Xenopus oocytes
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爪蟾卵母细胞中外源信使 RNA 诱导的血清素受体
DOI：
10.1098/rspb.1983.0062
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
I. Parker
中科院分区：
文献类型：
--
作者：
C. Gundersen;R. Miledi;I. Parker
当从大鼠脑中提取的多聚（A）+-mRNA注射到非洲爪蟾卵母细胞中时，它诱导卵母细胞膜中血清素受体的出现。将血清素应用于注射的卵母细胞，经过长时间的延迟后，引起膜电流振荡。该电流的平衡电势与氯化物平衡电势相对应。大鼠大脑 mRNA 似乎编码血清素受体翻译到卵母细胞膜中。血清素与这些受体的结合导致膜通道的开放。
When poly(A)+-mRNA, extracted from rat brain, was injected into Xenopus laevis oocytes, it induced the appearance of serotonin receptors in the oocyte membrane. Application of serotonin to injected oocytes elicited, after a long delay, oscillations in membrane current. The equilibrium potential of this current corresponded with the chloride equilibrium potential. It appears that rat brain mRNA encodes the translation of serotonin receptors into the oocyte membrane. The combination of serotonin with these receptors leads to the opening of membrane channels.