Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients.
Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients.
复制标题
囊性纤维化患者汗腺中血管活性肠肽神经支配不足。
DOI：
10.1126/science.4035357
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Said,SI
中科院分区：
文献类型：
--
作者：
Heinz-Erian,P;Dey,RD;Flux,M;Said,SI
与八名正常受试者相比，七名囊性纤维化患者的免疫反应性、血管活性肠肽神经纤维对腺泡和小汗腺导管的神经支配急剧减少。这种神经肽的神经支配减少已被证明可以促进血流以及水和氯在其他系统中上皮表面的移动，这可能是水含量降低以及上皮对氯和其他离子相对不渗透性的基本机制，这是囊性纤维化的特征。
The innervation of acini and ducts of eccrine sweat glands by immunoreactive, vasoactive intestinal peptide-containing nerve fibers was sharply reduced in seven patients with cystic fibrosis compared to eight normal subjects. The decrease in innervation by this neuropeptide, which has been shown to promote blood flow and the movement of water and chloride across epithelial surfaces in other systems, may be a basic mechanism for the decreased water content and relative impermeability of the epithelium to chloride and other ions that characterize cystic fibrosis.