Four New 2-(2-Phenylethyl)-4H-chromen-4-one Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibitory Activities on Neutrophil Pro-Inflammatory Responses
Four New 2-(2-Phenylethyl)-4H-chromen-4-one Derivatives from the Resinous Wood of Aquilaria sinensis and Their Inhibitory Activities on Neutrophil Pro-Inflammatory Responses
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DOI：
10.1055/a-0645-1437
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发表时间：
2018-06
期刊：
影响因子：
2.7
通讯作者：
Sin-Ling Wang;Hsiang‐Ruei Liao;M. Cheng;Chih-Wen Shu;Chun-Lin Chen;M. Chung;Jih-Jung Chen
中科院分区：
文献类型：
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作者：
Sin-Ling Wang;Hsiang‐Ruei Liao;M. Cheng;Chih-Wen Shu;Chun-Lin Chen;M. Chung;Jih-Jung Chen
摘要四个新的2-（2-苯乙基）-4H-苯并吡喃-4-酮衍生物，6-羟基-5-甲氧基-2-[2-（4′-甲氧基苯基）乙基]色酮（1），6，7-二甲氧基-2-[2-（2′-羟基苯基）乙基]色酮（2），5-羟基-6-甲氧基-2-[2-（3′-甲氧基苯基）乙基]-色酮（3）和7-氯-8-羟基-2-[2-（2-甲氧基苯基）乙基]-色酮（3），从白木香（Aquilariasinensis）中分离得到一个新的化合物[4′-（4′-甲氧基苯基）乙基]色酮（4），以及16个已知化合物（5-20）。其中7-甲氧基-2-[2-（4′-甲氧基苯基）乙基]色酮（5）为首次从天然来源中分离得到。新化合物的结构经波谱分析（1D和2D NMR，HR-ESI-MS，IR，UV）确定。包括1种化合物在内的9种化合物对人中性粒细胞响应50 µM的甲酰-L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸产生超氧阴离子的抑制率超过80%。
Abstract Four new 2-(2-phenylethyl)-4H-chromen-4-one derivatives, 6-hydroxy-5-methoxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (1), 6,7-dimethoxy-2-[2-(2′-hydroxyphenyl)ethyl]chromone (2), 5-hydroxy-6-methoxy-2-[2-(3′-methoxyphenyl)ethyl]-chromone (3), and 7-chloro-8-hydroxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (4), have been isolated from the resinous wood of Aquilaria sinensis, together with 16 known compounds (5–20). Among these, 7-methoxy-2-[2-(4′-methoxyphenyl)ethyl]chromone (5) was isolated from a natural source for the first time. The structures of the new compounds were established by spectroscopic analyses (1D and 2D NMR, HR-ESI-MS, IR, UV). Nine compounds, including 1 showed more than 80% inhibition of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine at 50 µM.