Association of Low Muscle Mass and Combined Low Muscle Mass and Visceral Obesity with Low Cardiorespiratory Fitness
Association of Low Muscle Mass and Combined Low Muscle Mass and Visceral Obesity with Low Cardiorespiratory Fitness
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DOI：
10.1371/journal.pone.0100118
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发表时间：
2014-06-17
期刊：
影响因子：
3.7
通讯作者：
Won, Jong Chul
中科院分区：
文献类型：
--
作者：
Kim, Tae Nyun;Park, Man Sik;Won, Jong Chul
目的：既往研究表明，低心肺适应性（CRF）、内脏肥胖和低肌肉质量可能具有共同的病理生理机制，如胰岛素抵抗和慢性炎症。在这项研究中，我们调查是否低CRF与低肌肉质量，内脏肥胖，内脏肥胖合并低muscle mass.Research设计和方法：CRF和低肌肉质量和合并低肌肉质量和内脏肥胖之间的关联进行了检查，在298个明显健康的成年人，年龄在20-70岁。低肌肉质量定义为使用骨骼肌质量指数（SMI），使用双能X线吸收测定法计算。内脏肥胖的定义是女性内脏脂肪面积（VFA）超过100厘米（2），男性超过130厘米（2）。我们根据SMI和VFA将参与者分为4个低肌肉质量/内脏肥胖组。结果：CRF水平与SMI呈正相关，与VFA呈负相关。低肌肉质量的个体比没有低肌肉质量的个体具有较低的CRF值。在调整了年龄、性别、生活方式因素以及胰岛素抵抗和炎症标志物后，CRF最低四分位数的参与者与最高四分位数的参与者相比，肌肉质量低的比值比（OR）为4.98（95%可信区间（CI）= 1.19-12.99;趋势P = 0.001），低肌肉质量和内脏肥胖合并的OR为31.46（95%CI = 4.31-229.68;趋势P = 0.001）。结论：CRF越低的个体，其低肌肉量和低肌肉量合并内脏型肥胖的风险越高。这些结果表明，低CRF可能是一个潜在的指标，低肌肉质量和低肌肉质量和内脏肥胖的韩国成年人。
Objective: Previous studies have shown that low cardiorespiratory fitness (CRF), visceral obesity and low muscle mass may share pathophysiological mechanisms, such as insulin resistance and chronic inflammation. In this study, we investigated whether low CRF is associated with low muscle mass, visceral obesity, and visceral obesity combined with low muscle mass.Research Design and Methods: The associations between CRF and low muscle mass and combined low muscle mass and visceral obesity were examined in 298 apparently healthy adults aged 20-70 years. Low muscle mass was defined using a skeletal muscle mass index (SMI) that was calculated using dual energy X-ray absorptiometry. Visceral obesity was defined as a visceral fat area (VFA) exceeding 100 cm(2) in women and 130 cm(2) in men. We classified the participants into 4 low muscle mass/visceral obesity groups according to SMI and VFA. CRF was measured using a cycle ergometer test.Results: CRF level correlated positively with SMI and negatively with VFA. Individuals with low muscle mass had lower CRF values than those without low muscle mass. After adjustment for age, sex, lifestyle factors, and markers for insulin resistance and inflammation, participants in the lowest quartile of CRF had an odds ratio (OR) for low muscle mass of 4.98 compared with those in the highest quartile (95% confidence interval (CI) = 1.19-12.99; P for trend = 0.001) and an OR for combined low muscle mass and visceral obesity of 31.46 (95% CI = 4.31-229.68; P for trend = 0.001).Conclusions: Individuals with lower CRF exhibited increased risk of low muscle mass and combined low muscle mass and visceral obesity. These results suggest that low CRF may be a potential indicator for low muscle mass and combined low muscle mass and visceral obesity in Korean adults.