Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
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DOI：
10.1079/bjn2002763
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发表时间：
2003-01-01
影响因子：
3.6
通讯作者：
Trayhurn, P
中科院分区：
文献类型：
--
作者：
Wood, IS;Trayhurn, P
在过去的2年中，已知的葡萄糖转运蛋白的数量已经大大增加。已鉴定出至少三种，最多六种Na+依赖性葡萄糖转运蛋白（SGLT 1-SGLT 6;基因名称SLC 5A）。类似地，促进性糖转运蛋白家族的13个成员（GLUT 1-GLUT 12和HMIT;基因名称SLC 2A）现在已被确认。这些不同的转运蛋白表现出不同的底物特异性，动力学特性和组织表达谱。不同基因产物的数量，以及某些组织和细胞中几种不同转运蛋白的存在（例如，白色脂肪组织中的GLUT 1、GLUT 4、GLUT 5、GLUT 8、GLUT 12和HMIT），表明葡萄糖递送到细胞中是相当复杂的过程。
The number of known glucose transporters has expanded considerably over the past 2 years. At least three, and up to six, Na+-dependent glucose transporters (SGLT1-SGLT6; gene name SLC5A) have been identified. Similarly, thirteen members of the family of facilitative sugar transporters (GLUT1-GLUT12 and HMIT; gene name SLC2A) are now recognised. These various transporters exhibit different substrate specificities, kinetic properties and tissue expression profiles. The number of distinct gene products, together with the presence of several different transporters in certain tissues and cells (for example, GLUT1, GLUT4, GLUT5, GLUT8, GLUT12 and HMIT in white adipose tissue), indicates that glucose delivery into cells is a process of considerable complexity.