Quantitative apparent diffusion coefficients and T2 relaxation times in characterizing contrast enhancing brain tumors and regions of peritumoral edema
Quantitative apparent diffusion coefficients and T2 relaxation times in characterizing contrast enhancing brain tumors and regions of peritumoral edema
复制标题
DOI：
10.1002/jmri.20335
复制
发表时间：
2005-06-01
影响因子：
4.4
通讯作者：
Nelson, SJ
中科院分区：
文献类型：
--
作者：
Oh, J;Cha, SM;Nelson, SJ
目的：探讨表观扩散系数（adc）和T2松弛时间在体内定量表征脑肿瘤细胞性和肿瘤相关性水肿中的潜在价值和关系。材料与方法：对26例新诊断为胶质瘤、脑膜瘤或转移瘤的患者行弥散加权及六回声多断面t2预备成像。感兴趣的肿瘤区域（通过造影剂增强确定）以及即时和周围水肿。坏死区域被排除。计算roi中adc和T2的中位数。结果：胶质瘤的adc与脑膜瘤或转移瘤的adc相似。胶质瘤的T2值（159.5 +/- 30.6msec）显著高于脑膜瘤或转移瘤的T2值（125.0 +/- 31.1 msec: P = 0.005）。脑膜瘤或转移瘤的即刻水肿T2值[226.0 +/- 44.1 msec]显著高于胶质瘤（203.5 +/- 32.8 msec; P = 0.033）。胶质瘤的外周水肿T2值（219.5 +/- 41.9 msec）与脑膜瘤或转移瘤的T2值（202.5 +/- 26.5 msec; P = 0.377）相似。两种肿瘤的即刻水肿和瘤周水肿adc和T2值均显著高于肿瘤。胶质瘤（r = 0.95, P < 0.0001）和脑膜瘤或转移瘤（r = 0.81, P < 0.0001）各区域adc和T2值显著相关。结论：非神经性肿瘤的即刻水肿T2值高于胶质瘤，提示肿瘤相关性水肿（血管源性或浸润性）可以通过T2值进一步表征。ADC值与T2值有显著相关性。(c) 2005 Wiley-Liss, Inc。
Purpose: To investigate the potential value and relationship of in vivo quantification of apparent diffusion coefficients (ADCs) and T2 relaxation times for characterization brain tumor cellularity and tumor-related edema.Materials and methods: A total of 26 patients with newly diagnosed gliomas, meningiomas, or metastases under-went diffusion-weighted and six-echo multisection T2-preperation imaging. Regions of interest tumor (as defind by contrast agent enhancement) and immediate and peripheral edema. Areas of necrosis were excluded. Median values of ADCs and T2 in the ROIs were calculated.Results :ADCs for gliomas were similar to those for meningiomas or metastases in all regions. Tumor T2 values for gliomas (159.5 +/- 30.6msec) were significantly higher than those for mengiomas or metastases [125.0 +/- 31.1 msec : P = 0.005]. Immediate-edema T2 values for meningiomas or metastases [226.0 +/- 44.1 msec] were significantly higher than those for gliomas (203.5 +/- 32.8 msec; P = 0.033). Peripheral-edema T2 values for gliomas (219.5 +/- 41.9 msec) were similar to those for meningiomas or metastases (202.5 +/- 26.5 msec; P = 0.377). Both immediate and peritumoral-edema ADCs and T2 values were significantly higher than those in tumor for both tumor types. ADCs and T2 values from all regions correlated significantly for gliomas (r = 0.95; P < 0.0001) and for meningiomas or metastases (r = 0.81; P < 0.0001).Conclusion: The higher imediate-edema T2 values for nonglial tumors than for gliomas suggest tumor-related edema (vasogenic vs. infiltrated) can be further characterized by using T2 values. There were significant correlations between ADC and T2 values.(c) 2005 Wiley-Liss, Inc.