CHANGE INDUCED BY RADIATION-THERAPY IN FDG UPTAKE IN NORMAL AND MALIGNANT STRUCTURES OF THE HEAD AND NECK - QUANTITATION WITH PET
CHANGE INDUCED BY RADIATION-THERAPY IN FDG UPTAKE IN NORMAL AND MALIGNANT STRUCTURES OF THE HEAD AND NECK - QUANTITATION WITH PET
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DOI：
10.1148/radiology.189.3.8234708
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发表时间：
1993-12-01
期刊：
影响因子：
19.7
通讯作者：
HAWKINS, RA
中科院分区：
文献类型：
--
作者：
REGE, SD;CHAIKEN, L;HAWKINS, RA
目得：定量分析头颈部正常结构中葡萄糖类似物2-[氟-18]氟-2-脱氧-D-葡萄糖（FDG）摄取的变化，并将其与接受放射治疗的头颈部肿瘤患者恶性结构中摄取的变化进行比较。对11例经活检证实的头颈部鳞状细胞癌患者在术前、术中、术后进行了研究，并在6周的正电子发射断层扫描（PET）-FDG成像放射治疗后。结构与小脑摄取FDG的比值在腺样体、舌扁桃体和腭扁桃体、腮腺、下颌下腺和舌下腺以及鼻甲、软腭和牙龈中测定辐射场内外的代谢率。扁桃体、鼻甲、软腭和牙龈的平均代谢率在治疗后没有显著变化。正常结构的FDG摄取不随放射治疗而改变。这一事实与头颈部鳞状细胞癌的FDG摄取形成鲜明对比，后者在治疗后显著降低（P <0.005）。
PURPOSE: To quantitate the changes induced in uptake of the glucose analog 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) in normal structures in the head and neck and compare these to the change in uptake in malignant structures in patients with head and neck tumors undergoing radiation therapy.MATERIALS AND METHODS: Eleven patients with biopsy-confirmed squamous cell carcinoma of the head and neck were studied before, during, and after a 6-week course of radiation therapy with positron emission tomography (PET)-FDG imaging. A ratio of FDG uptake in the structure compared with that in the cerebellum (termed metabolic ratio) within and outside of the field of radiation was determined in the adenoids; lingual and palatine tonsils; parotid, submandibular, and sublingual glands; and nasal turbinates, soft palate, and gingiva.RESULTS: The average metabolic ratio in the tonsils, nasal turbinates, soft palate, and gingiva did not change significantly with treatment.CONCLUSION: FDG uptake in normal structures does not change with radiation therapy. This fact is in marked contrast to the FDG uptake in squamous cell carcinomas in the head and neck, which decrease dramatically with treatment (P < .005).