Intake of α-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case-control study.
Intake of α-linolenic acid and other fatty acids in relation to the risk of bladder cancer: results from the New Hampshire case-control study.
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DOI：
10.1017/s0007114511001346
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Zeegers MP
中科院分区：
文献类型：
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作者：
Brinkman MT;Karagas MR;Zens MS;Schned AR;Reulen RC;Zeegers MP
由于研究较少、结果模棱两可以及缺乏关于重要膳食脂肪酸的信息，膳食脂肪在膀胱癌病因学中的作用目前尚不清楚。本研究的目的是调查主要膳食脂肪和脂肪酸的摄入与膀胱癌风险之间的关系。在美国新罕布什尔州进行了一项病例对照研究。收集322例患者和239例对照组的饮食资料，采用无条件logistic回归计算OR和95% CI。对潜在的混杂因素进行了调整：性别、年龄、吸烟状况、吸烟包年数、胆固醇和能量摄入。高摄入量（最高四分位数vs最低四分位数）α-亚麻酸（ALA） （OR 0.26, 95% CI 0.10, 0.65； P为趋势=0.01）和植物脂肪（OR 0.39, 95% CI 0.18, 0.86； P为趋势=0.03）可显著降低膀胱癌的发生率。多不饱和脂肪（OR 0.43, 95% CI 0.19, 0.98； P为趋势=0.07）和亚油酸（OR 0.43, 95% CI 0.19, 0.96； P为趋势=0.06）的比值降低具有临界统计学意义。这些脂肪和脂肪酸高度相关，在相互调整后，唯一可能的负相关是ALA。目前的研究结果表明ALA可能对膀胱癌的发生有保护作用；然而，需要在其他流行病学研究中进一步调查和复制。未来的研究应侧重于摄入不同膳食脂肪酸的类型、来源和数量。
The role of dietary fat in bladder cancer aetiology is currently unclear due to few studies, equivocal findings and a lack of information on important dietary fatty acids. The aim of the present study was to investigate the association between the intake of major dietary fats and fatty acids and the risk of bladder cancer. A case–control study was conducted in New Hampshire, USA. Dietary data were collected from 322 cases and 239 controls, and OR and 95 % CI were calculated using unconditional logistic regression. Adjustment was made for potential confounders: sex, age, smoking status, pack-years smoked, cholesterol and energy intake. Statistically significant reduced odds of bladder cancer were observed for high intakes (highest quartile v. lowest quartile) of α-linolenic acid (ALA) (OR 0.26, 95% CI 0.10, 0.65; P for trend=0.01) and vegetable fat (OR 0.39, 95% CI 0.18, 0.86; P for trend=0.03). Borderline statistically significant reduced odds were detected for polyunsaturated fat (OR 0.43, 95% CI 0.19, 0.98; P for trend=0.07) and linoleic acid (OR 0.43, 95% CI 0.19, 0.96; P for trend=0.06). These fats and fatty acids were highly correlated and following adjustment for each other, the only potential inverse association to remain was for ALA. The present findings suggest that ALA may have a protective role against developing bladder cancer; however, further investigation and replication in other epidemiological studies are required. Future research should focus on the type, source and quantities of different dietary fatty acids consumed.