Abnormal cortical thickness in heroin-dependent individuals
Abnormal cortical thickness in heroin-dependent individuals
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海洛因依赖者的皮质厚度异常
DOI：
10.1016/j.neuroimage.2013.10.021
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发表时间：
2014-03-01
期刊：
影响因子：
5.7
通讯作者：
Huang, Ruiwang
中科院分区：
文献类型：
--
作者：
Li, Meng;Tian, Junzhang;Huang, Ruiwang
从海洛因依赖的脑结构成像研究中积累的证据支持脑形态学改变与海洛因暴露之间的联系，特别是在灰质体积或灰质密度方面。然而，海洛因暴露对皮质厚度的影响以及皮质厚度与海洛因成瘾之间的关系尚不清楚。在这项研究中，我们从18名海洛因依赖者（HDIs）和15名健康对照者（HC）中获得了3D高分辨率脑结构磁共振成像（MRI）数据。使用FreeSurfer，我们检测到HDIs中皮质厚度的异常。基于顶点分析，与HC相比，HDI显示双侧上级额叶、左侧尾侧中额叶、右侧上级颞叶和右侧岛叶区域的皮质厚度显著降低，但左侧上级顶叶、双侧舌、左侧颞极、右侧下顶叶、右侧枕叶和右侧楔叶区域的皮质厚度显著增加。为了补充这些结果，进行了随后的ROI分析，结果显示左侧上级额沟、左侧楔前回、左侧距状沟、左侧前横侧副沟以及右侧内侧枕颞和舌沟的皮质厚度减少。这些区域与使用逐顶点分析识别的区域部分重叠。此外，我们发现右侧上级额区和右侧岛叶区的厚度与海洛因使用时间呈负相关。这些结果提供了令人信服的证据HDIs的皮质异常，也表明，海洛因使用的持续时间可能是一个关键因素与大脑的改变。(C)2013 Elsevier Inc. All rights reserved.
Accumulating evidence from brain structural imaging studies on heroin dependence has supported links between brain morphological alterations and heroin exposure, particularly in gray matter volume or gray matter density. However, the effects of heroin exposure on cortical thickness and the relationship between cortical thickness and heroin addiction are not yet known. In this study, we acquired 3D high-resolution brain structural magnetic resonance imaging (MRI) data from 18 heroin-dependent individuals (HDIs) and 15 healthy controls (HCs). Using FreeSurfer, we detected abnormalities in cortical thickness in the HDIs. Based on a vertex-wise analysis, the HDIs showed significantly decreased cortical thickness in the bilateral superior frontal, left caudal middle frontal, right superior temporal, and right insular regions compared to the HCs but significantly increased cortical thickness in the left superior parietal, bilateral lingual, left temporal pole, right inferior parietal, right lateral occipital, and right cuneus regions. To supplement these results, a subsequent ROI-wise analysis was performed and showed decreased cortical thickness in the left superior frontal sulcus, left precuneus gyrus, left calcarine sulcus, left anterior transverse collateral sulcus, and the right medial occipital temporal and lingual sulcus. These regions partially overlapped with the areas identified using the vertex-wise analysis. In addition, we found that the thickness in the right superior frontal and right insular regions was negatively correlated with the duration of heroin use. These results provide compelling evidence for cortical abnormality in HDIs and also suggest that the duration of heroin use may be a critical factor associated with the brain alteration. (C) 2013 Elsevier Inc. All rights reserved.