SLEEP HOMEOSTASIS IN THE RAT - SIMULATION OF THE TIME COURSE OF EEG SLOW-WAVE ACTIVITY
SLEEP HOMEOSTASIS IN THE RAT - SIMULATION OF THE TIME COURSE OF EEG SLOW-WAVE ACTIVITY
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DOI：
10.1016/0304-3940(91)90382-4
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发表时间：
1991-09-16
影响因子：
2.5
通讯作者：
BORBELY, AA
中科院分区：
文献类型：
--
作者：
FRANKEN, P;TOBLER, I;BORBELY, AA
根据睡眠调节的双过程模型，稳态过程S在清醒时增加，在睡眠时下降。 对于人类，S的时间过程已经从睡眠期间EEG慢波活动（SWA; 0.75-4.0 Hz范围内的谱功率密度）的变化中导出。 我们测试了该模型在大鼠睡眠中的适用性。 模拟是基于9只动物96小时实验中连续8秒的警戒状态。 S水平在非REM睡眠（NREMS）时期降低，在清醒或REM睡眠时期根据指数函数增加。 通过优化S的初始值和时间常数，得到了NREMS中SWA和S的小时值之间的密切拟合。 SWA在基线期间的双相时间过程中，其增强在初始恢复期后24小时睡眠剥夺，其随后的长期下冲中存在的模拟。 我们的结论是，睡眠稳态的概念化的两个过程模型可能是哺乳动物睡眠的一般属性。
According to the two-process model of sleep regulation, a homeostatic Process S increases during waking and declines during sleep. For humans, the time course of S has been derived from the changes in EEG slow-wave activity (SWA; spectral power density in the 0.75-4.0 Hz range) during sleep. We tested the applicability of the model to sleep in the rat. The simulation was based on the vigilance states for consecutive 8-s epochs of a 96-h experiment in 9 animals. The level of S was made to decrease in epochs of non-REM sleep (NREMS), and to increase in epochs of waking or REM sleep according to exponential functions. By optimizing the initial value and the time constants of S, a close fit between the hourly values of SWA in NREMS and of S was obtained. The biphasic time course of SWA during baseline, its enhancement in the initial recovery period after 24-h sleep deprivation, and its subsequent prolonged undershoot were present in the simulation. We conclude that sleep homeostasis as conceptualized in the two-process model may be a general property of mammalian sleep.