LTP in the lateral amygdala during cocaine withdrawal
LTP in the lateral amygdala during cocaine withdrawal
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DOI：
10.1111/j.1460-9568.2005.04538.x
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发表时间：
2006-01-01
影响因子：
3.4
通讯作者：
Bolshakov, VY
中科院分区：
文献类型：
--
作者：
Goussakov, I;Chartoff, EH;Bolshakov, VY
杏仁核在药物成瘾和滥用的几个方面起着关键作用。这种大脑结构与反映药物奖励、药物寻求和药物戒断的不良影响的行为有关。通过使用重复注射可卡因的模型来近似“狂欢”中毒，我们在大鼠身上发现，在可卡因戒断期间，奖励性脑刺激的影响减弱，通过颅内自我刺激（ICSS）行为的改变来量化。这些戒断的行为迹象伴随着侧杏仁核（LA）内谷氨酸能突触传递的增强，从而在组织切片中阻断电诱导的长期增强（LTP）。在可卡因戒断期间，突触增强在机制上类似于在对照切片中由电刺激引起的LTP，因为两种形式的突触可塑性都涉及谷氨酸释放的增加。这些结果表明，杏仁核内的LTP机制在反复暴露于可卡因的戒断过程中被招募。因此，他们提出了一种可能性，即成瘾行为的发展和维持可能至少部分地涉及特定杏仁核回路中的突触可塑性机制。
The amygdala plays key roles in several aspects of addiction to drugs of abuse. This brain structure has been implicated in behaviours that reflect drug reward, drug seeking, and the aversive effects of drug withdrawal. Using a model that involves repeated cocaine injections to approximate 'binge' intoxication, we show in rats that during cocaine withdrawal, the impact of rewarding brain stimulation is attenuated, as quantified by alterations in intracranial self-stimulation (ICSS) behaviour. These behavioural signs of withdrawal are accompanied by enhancements of glutamatergic synaptic transmission within the lateral amygdala (LA) that occlude electrically induced long-term potentiation (LTP) in tissue slices. Synaptic enhancements during periods of cocaine withdrawal are mechanistically similar to LTP induced with electrical stimulation in control slices, as both forms of synaptic plasticity involve an increase in glutamate release. These results suggest that mechanisms of LTP within the amygdala are recruited during withdrawal from repeated exposure to cocaine. As such, they raise the possibility that the development and maintenance of addictive behaviours may involve, at least in part, mechanisms of synaptic plasticity within specific amygdala circuits.