Tetrahydrocurcumin alleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota
Tetrahydrocurcumin alleviates allergic airway inflammation in asthmatic mice by modulating the gut microbiota
复制标题
四氢姜黄素通过调节肠道微生物群减轻哮喘小鼠的过敏性气道炎症
DOI：
10.1039/d1fo00194a
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发表时间：
2021
期刊：
影响因子：
6.1
通讯作者：
Yang Yan
中科院分区：
文献类型：
--
作者：
Wu Yinfan;Chen Yanqiu;Li Qin;Ye Xiaoyan;Guo Xingyue;Sun Lin;Zou Jinchao;Shen Yunqin;Mao Yuheng;Li Chunwei;Yang Yan
Dietary factors can reshape the gut microbiota and consequently affect disease progression. We previously reported that tetrahydrocurcumin (THC), the major active metabolite of curcumin (Cur), could ameliorate allergic inflammation in asthmatic mice. Herein, we aimed to investigate whether THC or Cur exerts anti-inflammatory effects on allergic asthma via modulating gut microbiota. Ovalbumin (OVA)-induced asthmatic mice were treated with Cur or THC, and the gut microbiota profiles were analyzed by 16S rRNA sequencing. Fecal microbiota transplantation (FMT) from Cur- or THC-fed donor mice was administered to OVA-induced asthmatic mice. Nasal symptoms and inflammation patterns of lungs and colons were evaluated in control, OVA-induced and Cur-or THC-treated mice. Both Cur and THC treatment could alter the compositions of the gut microbiota in asthmatic mice, characterized by a significant decrease in the ratio of Firmicutes to Bacteroidetes; Cur or THC supplementation also reduced the relative abundances of pro-inflammatory bacteria, e.g., Proteobacteria, Intestinimonas, Unidentified-Ruminococcaceae, and Lachnospiraceae, in OVA-induced mice. The relative abundances of Unidentified-Ruminococcaceae, Romboutsia, Intestinimonas, Akkermansia, and Mucispirillum were positively associated with the levels of Th2-related factors in asthmatic mice upon Cur or THC treatment. Moreover, THC-FMT showed better preventive effects than Cur-FMT on the development of allergic inflammation in OVA-induced mice, resulting in a reduction in symptoms and Th2-mediated inflammation in both lung and colon tissues. The results reveal that Cur- or THC-mediated alleviation of airway allergic inflammation is dependent on gut microbiota modulation. THC-induced gut microbiota may have therapeutic potential for asthma treatment.
