Plakortides, novel cyclic peroxides from the sponge Plakortis halichondrioides: Activators of cardiac SR-CA(2+)-pumping ATPase
Plakortides, novel cyclic peroxides from the sponge Plakortis halichondrioides: Activators of cardiac SR-CA(2+)-pumping ATPase
复制标题
DOI：
10.1021/np960087v
复制
发表时间：
1996-03-01
影响因子：
5.1
通讯作者：
Lahouratate, P
中科院分区：
文献类型：
--
作者：
Patil, AD;Freyer, AJ;Lahouratate, P
作为寻找新的肌浆网(肌浆网)钙泵活性激活剂的一部分，牙买加海绵Plakortis halichondrioides的乙酸乙酯提取物被证明是有效的。在生物测定的指导下对提取物进行分级，然后进行制备性薄层色谱和高效液相色谱分离，得到几个已知的和新的化合物。三种新的环状过氧化氢，菌斑F，G和H(3，4和5)是本报告的主题。通过对光谱数据的解释，确定了它们的结构，包括相对立体化学。微摩尔浓度的F-H(3-5)可显著促进SR对钙的摄取。
As part of a search for novel activators of Ca2+ pumping activity of cardiac SR-(sarcoplasmic reticulum), the EtOAc extract of the Jamaican sponge Plakortis halichondrioides was shown to be active. Bioassay-guided fractionation of the extract followed by preparative TLC and HPLC yielded several known and novel compounds. Three of the novel cyclic peroxides, plakortides F, G, and H (3, 4, and 5) are the subject of this report. Their structures including relative stereochemistry were established by interpretation of spectral data. Micromolar concentrations of plakortides F-H (3-5) were found to significantly enhance Ca2+ uptake by SR.