Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range
Spectroscopic photoacoustic imaging of lipid-rich plaques in the human aorta in the 740 to 1400 nm wavelength range
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DOI：
10.1117/1.jbo.17.6.061209
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发表时间：
2012-06-01
影响因子：
3.5
通讯作者：
Beard, Paul C.
中科院分区：
文献类型：
--
作者：
Allen, Thomas J.;Hall, Andrew;Beard, Paul C.
光谱光声成像有可能通过利用脂质和正常动脉组织在740至1400 nm波长范围内吸收光谱的差异来区分动脉组织的正常和富含脂质的动脉粥样硬化区域。高脂质浓度区域的识别将有助于识别可能破裂的斑块（易损斑块）。为了证明可视化富含脂质的斑块的可行性，在970和1210 nm的波长下，以正向模式对人动脉瘤样品进行成像。结果表明，从光声图像中获得的动脉壁结构和富脂斑块的边界与组织学一致。脂质的存在也被证实，通过比较的光声光谱（740至1400 nm）中获得的区域内的斑块的脂质的光谱特征。此外，富含脂质的斑块成功地成像，同时通过2.8 mm的血液照射样品，证明了在体内实施光声技术的可能性。(C)2012年，美国光电仪器工程师学会（SPIE）。[DOI：10.1117/1.JBO.17.6.061209]
Spectroscopic photoacoustic imaging has the potential to discriminate between normal and lipid-rich atheromatous areas of arterial tissue by exploiting the differences in the absorption spectra of lipids and normal arterial tissue in the 740 to 1400 nm wavelength range. Identification of regions of high lipid concentration would be useful to identify plaques that are likely to rupture (vulnerable plaques). To demonstrate the feasibility of visualizing lipid-rich plaques, samples of human aortas were imaged in forward mode, at wavelengths of 970 and 1210 nm. It was shown that the structure of the arterial wall and the boundaries of lipid-rich plaques obtained from the photoacoustic images were in good agreement with histology. The presence of lipids was also confirmed by comparing the photoacoustic spectra (740 to 1400 nm) obtained in a region within the plaque to the spectral signature of lipids. Furthermore, a lipid-rich plaque was successfully imaged while illuminating the sample through 2.8 mm of blood demonstrating the possibility of implementing the photoacoustic technique in vivo. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.6.061209]