Differences in interactions between azole drugs related to modifications in the 14-α sterol dernethylase gene (cyp51A) of Aspergillus fumigatus
Differences in interactions between azole drugs related to modifications in the 14-α sterol dernethylase gene (cyp51A) of Aspergillus fumigatus
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DOI：
10.1128/aac.49.5.2119-2121.2005
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发表时间：
2005-05-01
影响因子：
4.9
通讯作者：
Rodriguez-Tudela, JL
中科院分区：
文献类型：
--
作者：
Garcia-Effron, G;Mellado, E;Rodriguez-Tudela, JL
考察了不同类型的唑类药物的联合活性。对31株烟曲霉菌进行了检测，包括2株cyp51A(-)和1株cyp51B(-)基因敲除菌株以及不同耐药机制的唑类敏感和耐药菌株。除基因敲除的菌株外，伊曲康唑和伏立康唑对所有菌株均有协同作用。
The combined activity of different azole drugs was investigated. Thirty-one Aspergillus fumigatus strains were tested, including two cyp51A(-) and one cyp51B(-) gene-knockout strain and azole-susceptible and -resistant strains with different resistance mechanisms. The combination of itraconazole and voriconazole was synergistic for all strains except for those with gene knockouts.