Redefining Colorectal Cancer by Tumor Biology.
Redefining Colorectal Cancer by Tumor Biology.
复制标题
通过肿瘤生物学重新定义结直肠癌。
DOI：
10.1200/edbk_279867
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
J. Tie
中科院分区：
文献类型：
--
作者：
M. Salem;A. Puccini;J. Tie
Colorectal cancer treatment has undergone a paradigm shift. We no longer see this disease as a singular, anatomic tumor type but rather a set of disease subgroups. Largely because of a better understanding of cancer biology and the introduction and integration of molecular biomarkers-the premise of precision therapy-we are beginning to direct treatments toward the right tumor target(s) in the right patients. The field of molecular profiling is continually evolving, and new biomarkers are constantly being discovered that have investigational, therapeutic, and/or prognostic implications-negative or positive. To date, only a few biomarkers have sufficient actionable, clinical implication to earn international guideline-recommended routine testing. Hence, it is vital that the treating oncologist should know which biomarkers to assess, when in the treatment course to test for them, and how the test is to be done. Correct interpretation of profiling results is imperative. Herein, we focus on international guideline-recommended mutation testing for patients prior to their colorectal cancer treatment initiation. The clinical applications of circulating tumor DNA (ctDNA) in patients with metastatic disease, based on our current knowledge and capabilities, are also addressed.
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影响因子：
29.4
作者：
Boland CR;Goel A
通讯作者：
Goel A
影响因子：
28.2
作者：
Bardelli A;Corso S;Bertotti A;Hobor S;Valtorta E;Siravegna G;Sartore-Bianchi A;Scala E;Cassingena A;Zecchin D;Apicella M;Migliardi G;Galimi F;Lauricella C;Zanon C;Perera T;Veronese S;Corti G;Amatu A;Gambacorta M;Diaz LA Jr;Sausen M;Velculescu VE;Comoglio P;Trusolino L;Di Nicolantonio F;Giordano S;Siena S
通讯作者：
Siena S
影响因子：
158.5
作者：
Hampel, H;Frankel, WL;Papadopoulos, N
通讯作者：
Papadopoulos, N
影响因子：
28.2
作者：
Russo M;Siravegna G;Blaszkowsky LS;Corti G;Crisafulli G;Ahronian LG;Mussolin B;Kwak EL;Buscarino M;Lazzari L;Valtorta E;Truini M;Jessop NA;Robinson HE;Hong TS;Mino-Kenudson M;Di Nicolantonio F;Thabet A;Sartore-Bianchi A;Siena S;Iafrate AJ;Bardelli A;Corcoran RB
通讯作者：
Corcoran RB
影响因子：
28.2
作者：
Corcoran RB;André T;Atreya CE;Schellens JHM;Yoshino T;Bendell JC;Hollebecque A;McRee AJ;Siena S;Middleton G;Muro K;Gordon MS;Tabernero J;Yaeger R;O'Dwyer PJ;Humblet Y;De Vos F;Jung AS;Brase JC;Jaeger S;Bettinger S;Mookerjee B;Rangwala F;Van Cutsem E
通讯作者：
Van Cutsem E