Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis.
Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis.
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空肠弯曲杆菌 HS:19 与格林-巴利综合征和胃肠炎相关的分子群体遗传分析。
DOI：
10.1086/322008
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Piffaretti,JC
中科院分区：
文献类型：
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作者：
Nachamkin,I;Engberg,J;Gutacker,M;Meinersman,RJ;Li,CY;Arzate,P;Teeple,E;Fussing,V;Ho,TW;Asbury,AK;Griffin,JW;McKhann,GM;Piffaretti,JC
空肠弯曲杆菌HS:19感染与格林-巴-罗综合征（GBS）的发展有关。为了确定一个特定的HS:19克隆是否与GBS相关，使用多位点酶电泳（MLEE）分析了世界各地收集的分离株。83C的3个系统发育群中有34个电表型（et）。jejuniisolates。聚类1包含所有HS:19株，其中单个ET （ET4）占HS:19株的大部分。HS:19株毒株未在其他聚集性病例中出现。ET4包含来自不同地理位置的分离株，表明该克隆在全球传播。此外，ET4包含来自非复杂性肠炎和GBS患者的分离株，以及来自动物源的分离株。本研究结果表明，HS:19菌株组成了一个克隆群体，但不是单态群体，这与inc .中的非HS:19菌株不同。空肠。使用MLEE未发现与GBS相关的唯一克隆
Infection withCampylobacter jejuniserotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83C. jejuniisolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains withinC. jejuni. A unique clone associated with GBS was not identified by use of MLEE