An Efficient Method to Prepare 4-Aminoquinazolines: Potential Application to Conformation-Restricted Bleomycin Analogs
An Efficient Method to Prepare 4-Aminoquinazolines: Potential Application to Conformation-Restricted Bleomycin Analogs
复制标题
制备 4-氨基喹唑啉的有效方法：在构象限制的博莱霉素类似物中的潜在应用
DOI：
10.1002/jhet.238
复制
发表时间：
2009-11-01
影响因子：
2.4
通讯作者：
Bai, Xu
中科院分区：
文献类型：
--
作者：
Wei, Zhonglin;Zheng, Lianyou;Bai, Xu
为了提高P-3A的铁络合能力，4-氨基喹唑类化合物被设计为构象限制性博莱霉素类似物。提出了一种合成4-氨基喹唑啉杂环核的有效方法，该方法以较高的产率合成了4-氨基喹唑啉杂环核。展望了该方法在合成4-氨基喹唑啉博莱霉素类似物中的应用前景。
To enhance the iron-chelating ability of P-3A, 4-aminoquinazolines were designed as conformation-restricted bleomycin analogs. An efficient method was developed to prepare the 4-aminoquinazoline heterocyclic nucleus, which entails a two-step one-pot procedure leading to 4-aminoquinazolines in good yields. The application of this method to synthesis 4-aminoquinazoline bleomycin analogs is envisioned.