BLT1 signaling in epithelial cells mediates allergic sensitization via promotion of IL‐33 production
BLT1 signaling in epithelial cells mediates allergic sensitization via promotion of IL‐33 production
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DOI：
10.1111/all.13656
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发表时间：
2018-12
期刊：
影响因子：
12.4
通讯作者：
Y. Xiong;X. Cui;Wenjing Li;J. Lv;Li-Xia Du;W. Mi;Huabin Li;Zhengrong Chen;Q. Leng;Hong Zh
中科院分区：
文献类型：
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作者：
Y. Xiong;X. Cui;Wenjing Li;J. Lv;Li-Xia Du;W. Mi;Huabin Li;Zhengrong Chen;Q. Leng;Hong Zh
上皮细胞（EC）通过释放前2型细胞因子（特别是白细胞介素-33（IL-33）指导2型先天淋巴细胞（ILC 2）和树突状细胞（DC），在吸入性蛋白酶过敏原的过敏致敏中发挥关键作用。白三烯B4（LTB 4）是一种众所周知的白细胞化学引诱物，通过其受体1（BLT 1）的参与。然而，LTB 4-BLT 1轴通过激活EC在过敏性致敏中的作用仍然未知。
Epithelial cells (ECs) play a crucial role in allergic sensitization to inhaled protease allergens by instructing type 2 innate lymphoid cells (ILC2) and dendritic cells (DCs) via release of pro‐type 2 cytokines, particularly interleukin‐33 (IL‐33). Leukotriene B4 (LTB4) is a well‐known leukocyte chemoattractant via engagement of its receptor 1 (BLT1). However, the role of LTB4‐BLT1 axis in allergic sensitization via activation of ECs is still unknown.