Analyses of size and computed tomography densitometry parameters for prediction of keloid recurrence after postoperative electron beam radiation therapy.
Analyses of size and computed tomography densitometry parameters for prediction of keloid recurrence after postoperative electron beam radiation therapy.
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分析大小和计算机断层扫描密度参数，用于预测术后电子束放射治疗后瘢痕疙瘩复发。
DOI：
10.1111/srt.12775
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Murayama S.
中科院分区：
文献类型：
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作者：
Maemoto H;Ishigami K;Iraha S;Arashiro K;Kusada T;Ganaha F;Murayama S.
研究背景瘢痕疙瘩的大小是术后放疗后复发的危险因素。然而，目前尚不清楚长轴直径是否是评估病变大小的最合适的参数，因为瘢痕疙瘩通常形状不规则。此外，没有以前的研究已经调查的瘢痕疙瘩的计算机断层扫描（CT）密度参数作为潜在的预测复发术后radiotherapy.Materials and MethodsThe大小和CT密度参数进行了测量，为74个病变的CT图像质量足够的评价。结果肿瘤长轴径×短轴径×厚度与肿瘤体积相关性最强（ρ = 0. 96，P <0. 0001）;中位随访期为71个月，17处病变复发。多因素分析显示，长径×短径×厚度≥2.5 cm 3（危险比= 5.9，P = 0.0052）和体积≥1.2 ml（危险比= 4.3，P = 0.029）与瘢痕疙瘩复发显著相关，而仅长径与瘢痕疙瘩复发无关。CT值的平均值和最大值，密度直方图的峰度和偏度在复发和非复发病灶之间无显著性差异。结论长轴直径×短轴直径×厚度可能是一个比单独的长轴直径更好的参数。CT密度测定分析可能无助于预测术后电子束放疗后瘢痕疙瘩复发。
BackgroundThe lesion size is a risk factor for keloid recurrence after postoperative radiotherapy. However, it remains unclear whether the major axis diameter is the most appropriate parameter to evaluate lesion size, because keloids are often irregular in shape. Additionally, no previous study has investigated computed tomography (CT) densitometry parameters of keloids as potential predictors for recurrence after postoperative radiotherapy.Materials and MethodsThe size and CT densitometry parameters were measured for 74 lesions with CT images of sufficient quality for evaluation. The association between recurrence and size or CT densitometry parameters was analyzed for 64 lesions that could be followed up for 6 months or more.ResultsThe major axis diameter × minor axis diameter × thickness showed the strongest correlation with volume (ρ = 0.96,P< .0001). The median follow‐up period was 71 months, and 17 lesions recurred. The major axis diameter × minor axis diameter × thickness ≥2.5 cm3(hazard ratio = 5.9,P= .0052) and volume ≥1.2 ml (hazard ratio = 4.3,P= .029) were significantly associated with keloid recurrence under multivariate analyses, while the major axis diameter alone were not. The mean and maximum CT values, and the kurtosis and skewness of density histogram were not significantly different between recurrent and non‐recurrent lesions.ConclusionThe major axis diameter × minor axis diameter × thickness may be a better parameter than the major axis diameter alone. CT densitometry analyses may not help to predict keloid recurrence after postoperative electron beam radiotherapy.