Interactions between childhood maltreatment and combat exposure trauma on stress-related activity within the cingulate cortex: a pilot study.
Interactions between childhood maltreatment and combat exposure trauma on stress-related activity within the cingulate cortex: a pilot study.
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儿童虐待和战斗暴露创伤对扣带皮层内压力相关活动的相互作用：一项试点研究。
DOI：
10.1080/08995605.2019.1702831
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Herringa,RyanJ
中科院分区：
文献类型：
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作者：
Banihashemi,Layla;Wallace,MeredithL;Peng,ChristineW;Stinley,MarkM;Germain,Anne;Herringa,RyanJ
童年创伤可能会使大脑敏感，增加成年创伤暴露后适应不良应激反应的脆弱性。先前的工作已经确定扣带回是一个白色物质通路，可能对童年虐待造成的成年创伤敏感。在这项对年轻成年男性退伍军人（N = 28）的试点研究中，我们检查了由扣带回连接的优先感兴趣区域（ROI），包括参与认知过程和应激反应的区域。我们的目标是研究儿童期虐待和战斗暴露对扣带回相关ROI内压力相关活动的相互作用。因此，我们使用了一个轻度认知压力任务，一个性能滴定多源干扰任务（MSIT）。我们发现，童年虐待可以调节战斗暴露对背侧前扣带皮质（dACC，激活）、膝下ACC（sgACC，失活）和后中扣带皮质（pMCC，失活）内与压力相关的干扰诱发活动的影响。更大的战斗暴露与更大的dACC内的干扰诱发的激活，以及更严重的儿童虐待的个人之间的sgACC和pMCC失活。我们的研究结果表明，儿童虐待敏感这些前部和中部扣带区域以后的生活创伤。这些发现可能对认知控制、自主调节/应激反应以及对有害/厌恶刺激的反应产生影响，这可能导致精神脆弱性增加。
Childhood trauma may sensitize the brain, increasing vulnerability to maladaptive stress responses following adulthood trauma exposure. Previous work has identified the cingulum as a white matter pathway that may be sensitized to adulthood trauma by childhood maltreatment. In this pilot study of young adult male military veterans (N = 28), we examineda prioriregions of interest (ROIs) connected by the cingulum, including regions involved in cognitive processes and stress responses. Our goal was to examine the interaction between childhood maltreatment and combat exposure on stress-related activity within cingulum-associated ROIs. As such we utilized a mild cognitive stress task, a performance-titrated multi-source interference task (MSIT). We found that childhood maltreatment moderated the effect of combat exposure on stress-related, interference-evoked activity within the dorsal anterior cingulate cortex (dACC, activation), subgenual ACC (sgACC, deactivation) and posterior midcingulate cortex (pMCC, deactivation). Greater combat exposure was associated with greater interference-evoked activation within the dACC, and less sgACC and pMCC deactivation among individuals with more severe childhood maltreatment. Our findings suggest that child maltreatment sensitizes these anterior and mid-cingulate regions to later life trauma. These findings may have implications for cognitive control, autonomic regulation/stress reactivity, and responses to noxious/aversive stimuli, which may contribute to increased psychiatric vulnerability.