Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: Implications for mechanisms of bone loss
Effects of ethnicity and age or menopause on the remodeling and turnover of iliac bone: Implications for mechanisms of bone loss
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DOI：
10.1359/jbmr.1997.12.4.498
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发表时间：
1997-04-01
影响因子：
6.2
通讯作者：
Parfitt, AM
中科院分区：
文献类型：
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作者：
Han, ZH;Palnitkar, S;Parfitt, AM
我们分别测量了142名健康女性（年龄20 - 74岁，34名黑人和108名白色人，61名绝经前和81名绝经后）经髂骨双四环素标记后获得的髂骨活检组织中骨内膜松质、皮质内和皮质内分区的骨重建和骨转换的组织学指标。通过年龄/绝经和种族定义的四组的双向方差分析以及年龄主要变量的线性回归分析数据。相互作用项均不显著，黑人和白人之间的年龄回归斜率均不存在差异，表明种族和年龄/绝经的影响与先前报告的结构指数相同。因此，还分别分析了种族（绝经前和绝经后合并）和年龄/绝经（黑人和白人合并）对数据的影响。分析得出以下结论。(1)黑人总表面上的几何平均骨形成率比白人低25%;种族组之间的其他组织学差异在表面之间不一致。(2)血清骨钙素（OC），但不骨特异性碱性磷酸酶（BSAP）是低约15%，在黑人比白人。(3)黑人较低的骨转换率最有可能是定向的，而不是随机的，因为骨量较高，因此对疲劳损伤的敏感性降低。(4)与绝经前受试者相比，绝经后受试者的所有1类骨形成变量和3个骨吸收指数均显著升高，反映了激活频率增加33%。(5)BSAP，而不是OC，增加相对更多（66%）比骨形成率（BFR）。因此，BSAP比OC对更年期的影响更敏感，但OC比BSAP对种族的影响更敏感。(6)对于每个非细胞相关变量，骨内膜包膜的三个细分之间存在高度显著差异，所有1类形成变量在皮质内表面上最高，但变量之间的差异幅度和模式不一致。不同亚类对总骨形成率的贡献为松质骨54%，皮质内13%，皮质内33%。(7)先前报告的骨表面位置变化以及目前报告的激活频率和壁厚变化表明，年龄/绝经对松质骨和皮质内表面的侵蚀深度没有显著影响，但皮质内表面的侵蚀深度大幅增加。(8)由激素变化引起的骨转换增加最有可能是随机的，而不是定向的，因为它没有目的，但对骨骼完整性有有害影响。
We measured histologic indices of bone remodeling and turnover separately on the cancellous, endocortical, and intracortical subdivisions of the endosteal envelope, and on the combined total surface, in transiliac bone biopsies obtained after double tetracycline labeling in 142 healthy women, aged 20-74 years, 34 black and 108 white, 61 premenopausal and 81 postmenopausal. The data were analyzed by two-way analysis of variance of the four groups defined by age/menopause and ethnicity and by linear regression of the major variables on age. None of the interaction terms was significant and none of the regression slopes on age differed between blacks and whites, indicating that, as for the previously reported structural indices, the effects of ethnicity and of age/menopause are independent. Accordingly, the data were also analyzed separately for the effect of ethnicity (pre- and postmenopausal combined) and age/menopause (blacks and whites combined). The analyses led to the following conclusions. (1) The geometric mean bone formation rate on the combined total surface was 25% lower in blacks than in whites; other histologic differences between ethnic groups were inconsistent between surfaces. (2) Serum osteocalcin (OC) but not bone-specific alkaline phosphatase (BSAP) was lower by about 15% in blacks than in whites. (3) The lower bone turnover in blacks is most likely in the directed rather than in the stochastic component because of a higher bone mass and consequent reduced susceptibility to fatigue damage. (4) All Class 1 bone formation variables and the three resorption indices were significantly higher in the postmenopausal compared with the premenopausal subjects, reflecting a 33% increase in activation frequency. (5) BSAP, but not OC, was increased relatively more (66%) than the bone formation rate (BFR). Consequently, BSAP is more sensitive to the effects of menopause than OC, but OC is more sensitive to the effects of ethnicity than BSAP. (6) There were highly significant differences between the three subdivisions of the endosteal envelope for every non-cell-related variable, All Class 1 formation variables were highest on the endocortical surface, but the magnitude and pattern of the differences otherwise was inconsistent between variables. The contributions of the different subdivisions to the total bone formation rate were cancellous 54%, endocortical 13%, and intracortical 33%. (7) The previously reported changes in bone surface location, together with the presently reported changes in activation frequency and wall thickness indicated that there was no significant effect of age/menopause on erosion depth on the cancellous and intracortical surfaces but a large increase in erosion depth on the endocortical surface. (8) The increase in bone turnover that results from hormonal changes is most likely in the stochastic rather than in the directed component because it serves no purpose but has harmful effects on skeletal integrity.