Genetics of male and female sterility in hybrids of Drosophila pseudoobscura and D. persimilis.
Genetics of male and female sterility in hybrids of Drosophila pseudoobscura and D. persimilis.
复制标题
假暗果蝇和小果蝇杂交种雄性和雌性不育的遗传学。
DOI：
10.1093/genetics/116.4.555
复制
发表时间：
1987
期刊：
影响因子：
3.3
通讯作者：
Orr,HA
中科院分区：
文献类型：
--
作者：
Orr,HA
本文用回交分析法研究了拟暗果蝇与波斯果蝇杂交后代雄性和雌性不育的遗传基础。以前的研究通过测量睾丸大小间接评估男性生育能力;这些研究得出的结论是，男性不育是由于X染色体-常染色体不平衡造成的。通过对活动精子的产生进行直接评分，雄性不育在很大程度上是由于这两个物种的X和Y染色体上的基因不相容。这些物种已经分歧，在最低限度的9个位点影响杂交雄性不育。杂种雌性的半不育性似乎是X染色体-细胞质相互作用的结果;因此，X染色体对雄性和雌性杂种的不育性影响最大。这显然是第一次分析雌性不育的遗传基础，或影响两性的不育/不育，在动物杂交。
The genetic basis of male and female sterility in hybrids ofDrosophila pseudoobscura-Drosophila persimiliswas studied using backcross analysis. Previous studies indirectly assessed male fertility by measuring testis size; these studies concluded that male sterility results from anXchromosome-autosome imbalance. By directly scoring for the production of motile sperm, male sterility is shown to be largely due to an incompatibility between genes on theXandYchromosomes of these two species. These species have diverged at a minimum of nine loci affecting hybrid male fertility. Semisterility of hybrid females appears to result from anXchromosome-cytoplasm interaction; theXchromosome thus has the largest effect on sterility in both male and female hybrids. This is apparently the first analysis of the genetic basis of female sterility, or of sterility/inviability affecting both sexes, in an animal hybridization.