Risk of latent and active tuberculosis infection in travellers: a systematic review and meta-analysis.
Risk of latent and active tuberculosis infection in travellers: a systematic review and meta-analysis.
复制标题
旅行者潜在和活动性结核感染的风险：系统评价和荟萃分析。
DOI：
10.1093/jtm/taaa214
复制
发表时间：
2020
影响因子：
25.7
通讯作者：
C. Greenaway
中科院分区：
文献类型：
--
作者：
Tanya Diefenbach;Balqis Alabdulkarim;P. Deb;J. Pernica;G. Schwarzer;D. Menzies;I. Shrier;K. Schwartzman;C. Greenaway
介绍
在结核病发病率低的国家实现结核病的消除需要识别和治疗潜伏性结核病感染（LTBI）风险的个人。前往结核病高发国家旅行的人有潜在的结核病暴露风险。这项系统性综述和荟萃分析估计了从结核病发病率低的国家到结核病发病率高的国家旅行的个人中发生的LTBI和活动性结核病。
方法
从开始到2020年2月18日检索了5个电子数据库。我们确定了从结核病发病率低（<10例/100000人口）到中等（10 - 100/100000）或高（> 100/100000）国家旅行的个人中的LTBI事件和活动性结核病。我们使用对数转换比例（累积发生率）的随机效应模型进行荟萃分析和荟萃回归。亚组分析调查了旅行时间、旅行目的和目的地国结核病发病率的影响。
结果
我们的检索识别出799项研究，120项进行了全文综述，10项研究被纳入。这些研究包括1994年至2013年间观察到的1 154 673名旅行者，其中包括443名卫生保健工作者（HCW），1 068 636名军事人员和85 594名一般旅行者/志愿者。我们没有发现任何研究估计LTBI或活动性结核病在探亲访友（VFR）人群中的发病率。LTBI的总体累积发生率为2.3%，具有相当大的异质性。在平均/中位数长达6个月的旅行者中，HCW的LTBI累积发病率最高（4.3%），而军事（2.5%）和一般旅行者/志愿者（1.6%）的风险较低。荟萃回归没有发现基于旅行时间和目的地国家结核病发病率的LTBI事件差异。五项研究报告了活动性结核病例，总体汇总估计为每10万名旅行者120.7例。
结论
我们发现，旅行HCW是发展LTBI的最高风险。个人危险活动和旅行目的与旅行期间获得结核病感染的风险最相关。
INTRODUCTION
Achieving tuberculosis (TB) elimination in low TB incidence countries requires identification and treatment of individuals at risk for latent TB infection (LTBI). Persons travelling to high TB incidence countries are potentially at risk for TB exposure. This systematic review and meta-analysis estimates incident LTBI and active TB among individuals travelling from low to higher TB incidence countries.
METHODS
Five electronic databases were searched from inception to 18th February, 2020. We identified incident LTBI and active TB among individuals travelling from low (<10 cases/100000 population) to intermediate (10-100/100000) or high (>100/100000) TB incidence countries. We conducted a meta-analysis and meta-regression using a random effects model of log-transformed proportions (cumulative incidence). Subgroup analyses investigated the impact of travel duration, travel purpose, and TB incidence in the destination country.
RESULTS
Our search identified 799 studies, 120 underwent full-text review, and 10 studies were included. These studies included 1 154 673 travellers observed between 1994 and 2013, comprising 443 health care workers (HCW), 1 068 636 military personnel, and 85 594 general travellers/volunteers. We did not identify any studies that estimated incidence of LTBI or active TB among people travelling to visit friends and relatives (VFRs). The overall cumulative incidence of LTBI was 2.3%, with considerable heterogeneity. Among individuals travelling for a mean/median of up to 6 months, HCWs had the highest cumulative incidence of LTBI (4.3%), while the risk was lower for military (2.5%) and general travellers/volunteers (1.6%). Meta-regression did not identify a difference in incident LTBI based on travel duration and TB incidence in the destination country. Five studies reported cases of active TB, with an overall pooled estimate of 120.7 cases per 100 000 travellers.
CONCLUSIONS
We found that travelling HCWs were at highest risk of developing LTBI. Individual risk activities and travel purpose were most associated with risk of TB infection acquired during travel.
欧洲旅行者和移民中的传染病，EuroTravNet 2010。
DOI：
--
发表时间：
2012
期刊：
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
影响因子：
--
作者：
Gautret,P;Cramer,JP;Field,V;Caumes,E;Jensenius,M;Gkrania-Klotsas,E;deVries,PJ;Grobusch,MP;Lopez-Velez,R;Castelli,F;Schlagenhauf,P;HerviusAskling,H;vonSonnenburg,F;Lalloo,DG;Loutan,L;Rapp,C;Basto,F;SantosO'Connor,
通讯作者：
SantosO'Connor,