Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study.
Relationship between deep subcutaneous abdominal adipose tissue and metabolic syndrome: a case control study.
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DOI：
10.1186/s13098-016-0127-7
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发表时间：
2016
影响因子：
4.8
通讯作者：
Kim HN
中科院分区：
文献类型：
--
作者：
Kim SH;Chung JH;Song SW;Jung WS;Lee YA;Kim HN
与内脏脂肪组织（VAT）的特征相似，深层皮下脂肪组织（dSAT）与肥胖相关并发症密切相关。然而，dSAT和代谢综合征（MS）之间的关联尚不清楚。我们研究的目的是评估不同的腹部脂肪组织与心脏代谢危险因素和MS的关联。在365例无症状受试者（187例MS受试者和178例无MS受试者）中获得腹部计算机断层扫描（CT）图像。通过手动追踪L4-5水平的浅筋膜，将轴向图像分割为浅和深SAT。同时测定血清炎性细胞因子和脂肪因子的浓度。MS组脂联素水平显著低于对照组，但TNF-α、IL-6、ICAM、MCP-1和oxLDL水平显著高于对照组（p < 0.05）。所有炎性细胞因子和脂肪因子与VAT和dSAT面积之和（VDAT）相关（P趋势< 0.05），但未发现炎性细胞因子与sSAT之间存在显著相关性。在男性和女性中，dSAT与MS显著相关（OR 2.371; p < 0.001），而sSAT与MS之间的OR不显著（p = 0.597）。VDAT与MS之间的年龄校正OR（男性OR为8.359，女性OR为3.183，p < 0.001）高于VAT（男性OR为7.941，女性OR为2.570，p < 0.05）和dSAT（男性OR为2.954，女性OR为1.856，p < 0.05）。我们证明了dSAT与炎症和氧化应激增加有关，这表明dSAT是MS的重要决定因素。因此，腹部皮下脂肪应被视为两个功能不同的隔室，而不是一个单一的实体。
The deep subcutaneous adipose tissue (dSAT) is closely related to the obesity-associated complications similarly to the characteristics of visceral adipose tissue (VAT). However, the association between dSAT and metabolic syndrome (MS) is unclear. The purpose of our study was to evaluate the association of distinct abdominal adipose tissue with the cardiometabolic risk factors and MS. Abdominal computed tomography (CT) images were obtained in 365 asymptomatic subjects (187 subjects with MS and 178 without MS). The axial images segmented into superficial and deep SAT by manually tracing the fascia superficialis at L4–5 levels. The concentrations of serum inflammatory cytokines and adipokines were also measured. The MS group had significantly lower adiponectin levels but significantly higher levels of resistin, leptin, tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), intercellular adhesion molecule (ICAM), monocyte chemotactic protein-1 (MCP-1), and oxLDL than the control group (p < 0.05). All inflammatory cytokines and adipokines were associated with the sum of VAT and dSAT areas (VDAT) (P for trend < 0.05), but no significant correlation was found between inflammatory cytokines and sSAT. dSAT was significantly associated with MS in both men and women (OR 2.371; p < 0.001) whereas the ORs between sSAT and MS were not significant (p = 0.597). The age-adjusted ORs between VDAT and MS (OR of 8.359 in men and 3.183 in women, p < 0.001) were higher than those of VAT (OR of 7.941 in men and 2.570 in women, p < 0.05) and dSAT (OR of 2.954 in men and 1.856 in women, p < 0.05). We demonstrated that dSAT was associated with increased inflammation and oxidative stress, suggesting that dSAT is an important determinant of MS. Therefore, abdominal subcutaneous fat should be considered as two functionally distinct compartments rather than a single entity.