Modal DNA value and chromosome number in ovarian neoplasia. A clinical and histopathologic assessment
Modal DNA value and chromosome number in ovarian neoplasia. A clinical and histopathologic assessment
复制标题
卵巢肿瘤中的模态 DNA 值和染色体数目。
作者：
N. B. Atkin
根据其模态DNA值和染色体数目（23个肿瘤），或仅其模态DNA值（38个肿瘤），61例卵巢癌分为两个离散的组。低倍体（近二倍体）组中的肿瘤很少扩散到卵巢或卵巢以外，并且与高倍体（近三倍体-四倍体）组相比，预后明显更好。低倍性肿瘤的平均分化程度仅略高于高倍性肿瘤。从18个肿瘤中获得了一个以上的样本;在2个肿瘤中，不同区域存在差异，这可能代表了单个细胞系的区域多倍化。14例良性卵巢的DNA模式均为近二倍体，但粘液性囊腺瘤为近三倍体，浆液性囊腺瘤在某些区域为近二倍体，在其他区域为近四倍体。
On the basis of both their modal DNA values and chromosome numbers (23 tumors), or their modal DNA values alone (38 tumors), 61 ovarian carcinomas fell into 2 discrete groups. Tumors in the low‐ploidy (near‐diploid) group had less often spread beyond the ovary or ovaries and showed a significantly better prognosis as compared with those in the high‐ploidy (near‐triploid‐tetraploid) group. The low‐ploidy tumors were on the average only slightly more differentiated than the high‐ploidy tumors. More than one sample was obtained from 18 of the tumors; in 2 there were differences in different areas which possibly represented regional polyploidization of a single cell‐line. The DNA modes of 14 benign ovaries were near‐diploid, excepting a mucinous cystadenoma which was near‐triploid and a serous cystadenoma which was near‐diploid in some regions and near‐tetraploid in others.