CHARACTERIZATION OF IDIOTYPE-SPECIFIC I-ED-RESTRICTED T-SUPPRESSOR LYMPHOCYTES WHICH CONFINE IMMUNOGLOBULIN CLASS EXPRESSION TO IGM IN THE ANTI-ALPHA (1-GREATER-THAN-3)DEXTRAN B-1355-S RESPONSE OF BALB/C MICE
CHARACTERIZATION OF IDIOTYPE-SPECIFIC I-ED-RESTRICTED T-SUPPRESSOR LYMPHOCYTES WHICH CONFINE IMMUNOGLOBULIN CLASS EXPRESSION TO IGM IN THE ANTI-ALPHA (1-GREATER-THAN-3)DEXTRAN B-1355-S RESPONSE OF BALB/C MICE
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DOI：
10.1016/s0171-2985(11)80244-5
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发表时间：
1993-01-01
期刊：
影响因子：
2.8
通讯作者：
KOLSCH, E
中科院分区：
文献类型：
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作者：
AUSTRUP, F;KODELJA, V;KOLSCH, E
常规饲养的BALB/c小鼠对所谓的抗原α（1- > 3）葡聚糖B 1355 S（Dex）的体液免疫应答主要是IgM类。免疫应答的特征还在于Igh（a）同种异型连锁和公共独特型（Id）J558和MOPC 104的优势。在无菌饲养的BALB/c和用相同抗原免疫的BALB/c nu/nu小鼠中，观察到公共Id的额外IgG应答。类表达的调节的分析揭示了特定的Ts细胞在正常胸腺小鼠中的存在，其必须通过暴露于环境细菌抗原而在产前或围产期被激活。它们允许或强制Dex特异性B细胞分化成By记忆细胞，而不允许进一步发育成产生IgG的浆细胞。这些脾Ts细胞的类似物现已被克隆并鉴定为I-E（d）限制性Id特异性T细胞，其具有上述脾Ts细胞的性质。本文描述了Ts细胞克隆178-4的表型和功能特性。它评估了该克隆在控制有效的抗细菌IgM介导的免疫力的条件下，其中一类切换到IgG抗体的生产被积极抑制的作用;可能作为一种措施，以避免危险的自身免疫反应的基础上的交叉反应和抗原模拟多糖抗原之间。
The humoral immune response of conventionally raised BALB/c mice to the so-called antigen alpha (1- > 3) Dextran B 1355 S (Dex) is predominantly of the IgM class. The response is further characterized by Igh(a) allotype linkage and the dominance of the public idiotypes (Id) J558 and MOPC 104. In germfree raised BALB/c and in BALB/c nu/nu mice immunized with the same antigen an additional IgG response of the public Id is observed. Analysis of the regulation of the class expression reveals existence of specific Ts cells in euthymic mice which must have been activated pre- or perinatally by exposure to environmental bacterial antigens. They permit or enforce differentiation of Dex-specific B cells into By memory cells without allowing further development into IgG producing plasma cells. An analogue of these splenic Ts cells has now been cloned and identified as an I-E(d) restricted Id-specific T cell with exactly the properties ascribed above to the splenic Ts cells. This paper describes phenotypical and functional properties of the Ts cell clone 178-4. It evaluates this clone's role in controlling efficient anti-bacterial IgM-mediated immunity under conditions where a class switch to IgG antibody production is actively suppressed; possibly as a measure to avoid hazardous autoimmune reactions on the basis of crossreaction and antigenic mimicry between polysaccharide antigens.