GLYCATED HEMOGLOBIN OF FRACTIONATED ERYTHROCYTES, GLYCATED ALBUMIN, AND PLASMA FRUCTOSAMINE DURING PREGNANCY
GLYCATED HEMOGLOBIN OF FRACTIONATED ERYTHROCYTES, GLYCATED ALBUMIN, AND PLASMA FRUCTOSAMINE DURING PREGNANCY
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DOI：
10.1016/s0002-9378(11)91719-0
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发表时间：
1992-11-01
影响因子：
9.8
通讯作者：
KOZU, H
中科院分区：
文献类型：
--
作者：
KURISHITA, M;NAKASHIMA, K;KOZU, H
目的：通过测定血浆果糖胺、糖化白蛋白和轻、密红细胞的稳定糖化血红蛋白来评价妊娠期间的糖代谢。研究设计：糖耐量异常组包括妊娠期糖尿病患者和75克口服糖耐量试验中有一个异常值的患者。毛细管离心分离法分离红细胞。结果：正常妊娠中，轻红细胞糖化血红蛋白在妊娠中期和晚期降低（前三个月为3.42% +/- 0.62% [mean +/- SD] [n = 306]，后三个月为2.15% +/- 0.48% [n = 353]，后三个月为2.06% +/- 0.58% [n = 300]），而致密红细胞在妊娠晚期升高（前三个月为4.59% +/- 0.46%，后三个月为4.70% +/- 0.49%，后三个月为5.29% +/- 0.73%）。糖化白蛋白和果糖胺遵循与轻红细胞相似的模式。糖耐量异常组妊娠早期和晚期轻红细胞糖化血红蛋白、妊娠晚期致密红细胞糖化血红蛋白和糖化白蛋白水平均显著升高。结论：妊娠后期非分形糖化血红蛋白的双相变化是轻红细胞低糖化血红蛋白和致密红细胞高糖化血红蛋白的总和。分离红细胞稳定的糖化血红蛋白和糖化白蛋白准确反映了妊娠期母体糖代谢。
OBJECTIVE: To evaluate glucose metabolism during pregnancy, we measured plasma fructosamine, glycated albumin, and the stable glycated hemoglobin of the light and dense erythrocytes.STUDY DESIGN: The abnormal glucose tolerance group comprised patients with gestational diabetes and those with one abnormal value on a 75 gm oral glucose tolerance test. Erythrocyte fractionation was performed by capillary centrifugation.RESULTS: In normal pregnancy glycated hemoglobin of the light erythrocytes was reduced in the second and third trimesters (3.42% +/- 0.62% [mean +/- SD] [n = 306] in the first trimester, 2.15% +/- 0.48% [n = 353] in the second, and 2.06% +/- 0.58% [n = 300] in the third), and dense erythrocytes were higher in the third trimester (first 4.59% +/- 0.46%, second 4.70% +/- 0.49%, third 5.29% +/- 0.73%). Glycated albumin and fructosamine followed a pattern similar to the light erythrocytes. The group with abnormal glucose tolerance had significantly higher levels of glycated hemoglobin of the light erythrocytes in the first and third trimesters and glycated hemoglobin of the dense erythrocytes and glycated albumin in all trimesters.CONCLUSION: The biphasic change in nonfractionated glycated hemoglobin is the sum of the lower glycated hemoglobin of the light erythrocytes and the higher glycated hemoglobin of the dense erythrocytes in late pregnancy. The stable glycated hemoglobin of fractionated erythrocytes and the glycated albumin accurately reflect maternal glucose metabolism during pregnancy.