BASIC FIBROBLAST GROWTH-FACTOR PREVENTS DEATH OF LESIONED CHOLINERGIC NEURONS INVIVO
BASIC FIBROBLAST GROWTH-FACTOR PREVENTS DEATH OF LESIONED CHOLINERGIC NEURONS INVIVO
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DOI：
10.1038/332360a0
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发表时间：
1988-03-24
期刊：
影响因子：
64.8
通讯作者：
COTMAN, CW
中科院分区：
文献类型：
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作者：
ANDERSON, KJ;DAM, D;COTMAN, CW
切断投射到海马结构的胆碱能神经元的轴突导致这些细胞中的大多数死亡1，2。以前的研究表明，在病变之前或同时给予神经生长因子将防止这种细胞死亡3，4。在这里，我们表明，碱性成纤维细胞生长因子（FGF）给药到大脑中减少胆碱能神经元的死亡后，在内侧隔和斜角带的布罗卡横断其轴突，在年轻的成年和老年大鼠。此外，FGF可以部分防止胆碱能神经元的死亡，即使在轴突横断后两天给药。这些结果表明FGF在基底前脑胆碱能神经元的正常支持中可能具有功能，但其活性范围可能更广，因为FGF也支持体外非胆碱能神经元5，6，它位于许多中枢神经系统神经元7中，并且在脑中以相对高的浓度发现8。
Cutting the axons of the cholinergic neurons that project to the hippocampal formation results in death of most of these cells1,2. Previous studies have shown that administration of nerve growth factor before or at the same time as the lesion will prevent this cell death3,4. Here we demonstrate that basic fibroblast growth factor (FGF) administered into the brain reduces the death of cholinergic neurons in the medial septum and diagonal band of Broca after transection of their axons, in both young adult and aged rats. Moreover, FGF can partially protect against death of cholinergic neurons even when administered two days after axonal transection. These results indicate a possible function for FGF in the normal support of basal forebrain cholinergic neurons, but its range of activity could be wider, for FGF also supports non-cholinergic neuronsin vitro5,6, it is localized in many of the central nervous system neurons7, and it is found in relatively high concentrations in the brain8.