Successful use of intravenous cyclophosphamide pulse therapy for interstitial lung disease in a patient with systemic sclerosis on hemodialysis.
Successful use of intravenous cyclophosphamide pulse therapy for interstitial lung disease in a patient with systemic sclerosis on hemodialysis.
复制标题
静脉内环磷酰胺脉冲疗法成功用于治疗血液透析系统性硬化症患者的间质性肺疾病。
DOI：
10.1111/1346-8138.12495
复制
发表时间：
2014
影响因子：
3.1
通讯作者：
and Sato S
中科院分区：
文献类型：
--
作者：
Takahashi T;Asano Y;Sunaga R;Ichimura Y;Taniguchi T;Yamamoto M;Tamaki Z;Takekoshi T;Mitsui H;Sugaya M;Ohse T;and Sato S
间质性肺疾病和硬皮病肾危象是系统性硬化症的主要并发症，在弥漫性皮肤亚型患者中偶尔并存。我们在此报告一例因硬皮病肾危象病史而行血液透析的弥漫性皮肤系统性硬化症病例，其间质性肺疾病可用半量静脉注射安全有效地治疗。环磷酰胺脉冲。讨论了环磷酰胺的剂量和血液透析的时机，以达到有效和低毒的目的。
Interstitial lung disease and scleroderma renal crisis are major complications of systemic sclerosis, which occasionally coexist in patients with the diffuse cutaneous subtype. We herein report a case of diffuse cutaneous systemic sclerosis under hemodialysis due to a previous history of scleroderma renal crisis, whose interstitial lung disease was effectively and safely treated with a half dose of i.v. cyclophosphamide pulse. The dose of cyclophosphamide and the timing of hemodialysis leading to efficacy and low toxicity are discussed.