Corneal Densitometry as a Predictive Diagnostic Tool for Visual Acuity Results After Descemet Membrane Endothelial Keratoplasty
Corneal Densitometry as a Predictive Diagnostic Tool for Visual Acuity Results After Descemet Membrane Endothelial Keratoplasty
复制标题
DOI：
10.1016/j.ajo.2018.10.002
复制
发表时间：
2019-02-01
影响因子：
4.2
通讯作者：
Bachmann, Bjoern O.
中科院分区：
文献类型：
--
作者：
Schaub, Friederike;Gerber, Fanny;Bachmann, Bjoern O.
) 目的：我们试图研究患有角膜内皮疾病的眼睛术前角膜后向散射与后弹力层内皮角膜移植术 (DMEK) 后视力结果之间的相关性。设计：回顾性介入病例系列。方法：科隆大学眼科中心首批 551 名连续接受 DMEK 的患者，这些患者具有可用的术前角膜光密度测量值（角膜光后向散射测量值）使用基于 Scheimpflug 的 Oculus Pentacam 角膜密度测量模块测量的灰度单位）进行资格筛选。最佳眼镜矫正视力（BSCVA）结果与密度测量数据进行回顾性相关。在 4 个角膜层（即前层、中央层、后层和总层）和 4 个角膜环中获得密度测量数据。术前和术后 BSCVA 结果与密度测量数据相关。进行了接受者操作特征分析。结果：四百一十二只眼睛可用于分析。 DMEK 手术后 3、6、12 和 24 个月随访时的视力结果显着改善 (P < .001)。角膜后向散射与术前 BSCVA 结果存在中等相关性。与术后 BSCVA 结果的中度关联主要存在于所有术后时间点的前层和中央层的光密度测定值之间，在角膜中心更明显。后层与术后 BSCVA 增益的相关性最差。接受者操作特征分析显示，光密度值的最佳预测能力是角膜的 2-6 mm 环形区。结论：患有角膜内皮疾病的眼睛的角膜后向散射与 DMEK 手术后的术后 BSCVA 结果相关。因此，早期 DMEK 手术似乎对长期 BSCVA 结果具有积极影响。 （(C) 2018 Elsevier Inc. 保留所有权利。）
) PURPOSE: We sought to investigate correlations between preoperative corneal backscatter with visual acuity results after Descemet membrane endothelial keratoplasty (DMEK) in eyes with corneal endothelial disorders.DESIGN: Retrospective interventional case series.METHODS: The first 551 consecutive patients with DMEK at the Center of Ophthalmology, University of Cologne who had available preoperative corneal densitometry values (corneal light backscatter measured in gray scale units) measured with the Scheimpflug-based Oculus Pentacam corneal densitometry module were screened for eligibility. Best spectacle-corrected visual acuity (BSCVA) results were retrospectively correlated with densitometry data. Densitometry data were obtained in 4 corneal layers (ie, anterior, central, posterior, and total layers) and 4 annuli. Pre- and postoperative BSCVA results were correlated with densitometry data. Receiver operating characteristic analyses were performed.RESULTS: Four hundred twelve eyes were available for the analyses. Visual acuity results improved significantly after DMEK surgery at 3,6, 12, and 24 months of follow-up (P < .001). Corneal backscatter correlated moderately with preoperative BSCVA results. Moderate associations to postoperative BSCVA results could predominantly be found between densitometry values of the anterior and central layer more pronounced in the center of the cornea for all postoperative timepoints. The posterior layer correlated worst with postoperative gain in BSCVA. Receiver operating characteristic analyses revealed that the best predictive power of densitometry values was for the 2-6 mm annular zone of the cornea.CONCLUSION: Corneal backscatter in eyes with corneal endothelial disorders correlates with postsurgical BSCVA results after DMEK surgery. Therefore, early DMEK surgery seems to have a positive impact on long-term BSCVA results. ((C) 2018 Elsevier Inc. All rights reserved.)