The semantic interference effect in the picture-word paradigm: An event-related fMRI study employing overt responses
The semantic interference effect in the picture-word paradigm: An event-related fMRI study employing overt responses
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DOI：
10.1002/hbm.1054
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发表时间：
2001-12-01
影响因子：
4.8
通讯作者：
Muthiah, S
中科院分区：
文献类型：
--
作者：
de Zubicaray, GI;Wilson, SJ;Muthiah, S
本研究采用事件相关功能磁共振成像（fMRI）技术研究了图片-词语任务中语义干扰（SI）效应的神经反应。单词产生的独立阶段模型假设SI效应发生在概念加工水平（Levelt et al. [1999]：Behav Brain Sci 22：1-75），而交互模型假设它发生在语音检索（Starreveld and La Heij [1996]：J Exp Psychol Learn Mem Cogn 22：896-918）。在这两种类型的模型中，SI效应的解析是由于竞争性的、扩散性的激活而发生的，而不涉及抑制性链接。通过随机向参与者提供语义相关和词汇控制干扰物条件下的试验，并采集与每次试验的估计峰值血流动力学反应一致的图像体积，对这些假设进行了测试。在没有扫描仪噪音的情况下，出现了明显的图片名称的发声，从而收集了反应时间（RT）数据。RT数据的分析证实了SI效应。在SI效应期间表现出不同血流动力学反应的区域包括左侧颞中回中段、左侧颞后上级回、左侧前扣带回皮质和双侧眶内侧前额叶皮质。在额眼区、左顶下小叶、右前颞叶和枕叶皮质中观察到额外的反应。结果被解释为间接支持的互动模式，允许扩散激活之间的概念处理和语音检索水平的单词生产。此外，数据证实，选择性注意/反应抑制具有解决SI效应的作用，类似于Stroop干扰的解决方式。我们的结论是，神经影像学研究可以提供有关词汇系统的神经解剖学组织的信息，这些信息可能被证明对限制词汇产生的理论模型有用。(C)2001 Wiley-Liss，Inc.
We used event-related functional magnetic resonance imaging (fMRI) to investigate neural responses associated with the semantic interference (SI) effect in the picture-word task. Independent stage models of word production assume that the locus of the SI effect is at the conceptual processing level (Levelt et al. [1999]: Behav Brain Sci 22:1-75), whereas interactive models postulate that it occurs at phonological retrieval (Starreveld and La Heij [1996]: J Exp Psychol Learn Mem Cogn 22:896-918). In both types of model resolution of the SI effect occurs as a result of competitive, spreading activation without the involvement of inhibitory links. These assumptions were tested by randomly presenting participants with trials from semantically-related and lexical control distractor conditions and acquiring image volumes coincident with the estimated peak hemodynamic response for each trial. Overt vocalization of picture names occurred in the absence of scanner noise, allowing reaction time (RT) data to be collected. Analysis of the RT data confirmed the SI effect. Regions showing differential hemodynamic responses during the SI effect included the left mid section of the middle temporal gyrus, left posterior superior temporal gyrus, left anterior cingulate cortex, and bilateral orbitomedial prefrontal cortex. Additional responses were observed in the frontal eye fields, left inferior parietal lobule, and right anterior temporal and occipital cortex. The results are interpreted as indirectly supporting interactive models that allow spreading activation between both conceptual processing and phonological retrieval levels of word production. In addition, the data confirm that selective attention/response suppression has a role in resolving the SI effect similar to the way in which Stroop interference is resolved. We conclude that neuroimaging studies can provide information about the neuroanatomical organization of the lexical system that may prove useful for constraining theoretical models of word production. (C) 2001 Wiley-Liss, Inc.