Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna
Acute and chronic effects of testosterone and 4-hydroxyandrostenedione to the crustacean Daphnia magna
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DOI：
10.1016/j.ecoenv.2008.02.020
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发表时间：
2008-11-01
影响因子：
6.8
通讯作者：
Soares, Amadeu M. V. M.
中科院分区：
文献类型：
--
作者：
Barbosa, Isabel R.;Nogueira, Antonio J. A.;Soares, Amadeu M. V. M.
在全球的地表沃茨中都检测到了类固醇化合物。这些生物活性化学品的生态影响在很大程度上是未知的。研究了睾酮和4-羟基雄烯二酮对大型蚤的毒性。急性毒性试验表明，6.20mgL（-1）的睾酮，测试的最高浓度，对水蚤没有影响，而4-羟基雄烯二酮的EC 50为4.26 mg L-1。使用存活率、体长、繁殖力和生育力作为终点进行慢性毒性试验。长期睾酮暴露降低D。在0.31 ~ 2.48mgL（-1）浓度范围内，对麦蛾的生殖力和育性有显著影响。繁殖力的显著下降与流产卵的增加有关。长期接触0.84mgL（-1）的4-羟基雄烯二酮会增加新生儿的死亡率。在高于这些化合物的实测环境浓度的浓度下观察到慢性毒性效应。尽管如此，水蚤的生殖损害很可能发生在环境水平上，作为对长期接触的最终反应。(C)2008年爱思唯尔公司All rights reserved.
Steroid compounds have been globally detected in surface waters. The ecological impacts of these biologically active chemicals are largely unknown. Toxicity of testosterone and 4-hydroxyandrostenedione was assessed for the freshwater cladoceran Daphnia magna. Acute toxicity tests showed that 6.20mgL(-1) of testosterone, the highest concentration tested, did not have effect on the daphnids, whereas 4-hydroxyandrostenedione had an EC50 of 4.26 mg L-1. Chronic toxicity tests were carried out using survival, body length, fecundity, and fertility as endpoints. Long-term testosterone exposure reduced D. magna fecundity and fertility at concentrations ranging from 0.31 to 2.48mgL(-1). The significant decrease in fecundity was associated with an increase in aborted eggs. Long-term 4-hydroxyandrostenedione exposure at 0.84mgL(-1) increased the mortality of the neonates. The chronic toxicity effects were observed at concentrations higher than the measured environmental concentrations of these compounds. Nevertheless, the reproductive impairment of the daphnids is likely to occur at environmental levels as an ultimate response to long-term exposure. (C) 2008 Elsevier Inc. All rights reserved.