HISTOPATHOLOGY OF EXPERIMENTAL SPINAL-CORD TRAUMA - COMPARISON OF TREATMENT WITH TRH, NALOXONE, AND DEXAMETHASONE
HISTOPATHOLOGY OF EXPERIMENTAL SPINAL-CORD TRAUMA - COMPARISON OF TREATMENT WITH TRH, NALOXONE, AND DEXAMETHASONE
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DOI：
10.1007/bf02576273
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发表时间：
1992-06-01
期刊：
影响因子：
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通讯作者：
KURTSOY, A
中科院分区：
文献类型：
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作者：
AKDEMIR, H;PASAOGLU, A;KURTSOY, A
比较了促甲状腺激素释放激素（TRH）、纳洛酮和地塞米松对白化病大鼠实验性脊髓损伤的治疗效果。所有动物均采用Rivlin和Tator的应用夹法造成截瘫。在损伤后45分钟和120分钟，以两种剂量的推注方式腹膜内给予治疗。将动物随机分为四个实验组：（1）TRH（0.6 mg/剂），（2）纳洛酮（0.8 mg/剂），（3）地塞米松（0.6 mg/剂）和（4）对照（生理盐水）。TRH治疗组大鼠的组织病理学评分明显优于纳洛酮或地塞米松治疗组（Kruskal沃利斯：24.058 P
The results of treatment with thyrotropin-releasing hormone (TRH), naloxone and dexamethasone treatments albino rats with experimental spinal cord injury were compared. All the animals were made paraplegic by the application clip method of Rivlin and Tator. Treatment was administered i.p. as bolus injections in two doses, at 45 and 120 min after the injury. Animals were allocated randomly to four experimental groups: (1) TRH (0.6 mg per dose), (2) naloxone (0.8 mg per dose), (3) dexamethasone (0.6 mg per dose), and (4) control (saline). TRH-treated rats showed significantly better histopathological scores than either naloxone or dexamethasone-treated ones (Kruskal Wallis: 24.058 P