Laboratory investigation of human deaths from vampire bat rabies in Peru.
Laboratory investigation of human deaths from vampire bat rabies in Peru.
复制标题
秘鲁吸血蝙蝠狂犬病导致人类死亡的实验室调查。
DOI：
10.4269/ajtmh.1999.60.502
复制
发表时间：
1999
期刊：
影响因子：
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通讯作者：
C. Rupprecht
中科院分区：
文献类型：
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作者：
C. Warner;S. Zaki;W. Shieh;S. Whitfield;Jean S. Smith;L. Orciari;J. Shaddock;M. Niezgoda;Charles W. Wright;C. Goldsmith;D. Sanderlin;P. Yager;C. Rupprecht
1996年春，向疾病控制和预防中心报告了秘鲁偏远地区发生的多起急性发热性疾病病例，造成数人死亡。这些病例的临床症状包括吞咽困难和脑炎。由于蝙蝠叮咬在受影响地区很常见，初步临床诊断为狂犬病。然而，狂犬病被低估主要是因为报告的患者恢复。CDC收到了两例致命病例的脑组织样本，用于实验室确认狂犬病诊断。对福尔马林固定的组织进行的一系列广泛测试证实了狂犬病病毒抗原和核酸的存在。该病毒被证明与吸血蝙蝠狂犬病分离株关系最密切。这些结果表明，在急性发热性脑炎的鉴别诊断中，特别是在可能发生吸血蝙蝠暴露的地区，保持狂犬病的重要性。
In the spring of 1996, multiple cases of an acute febrile illness resulting in several deaths in remote locations in Peru were reported to the Centers for Disease Control and Prevention (CDC). The clinical syndromes for these cases included dysphagia and encephalitis. Because bat bites were a common occurrence in the affected areas, the initial clinical diagnosis was rabies. However, rabies was discounted primarily because of reported patient recovery. Samples of brain tissue from two of the fatal cases were received at CDC for laboratory confirmation of the rabies diagnosis. An extensive array of tests on the formalin-fixed tissues confirmed the presence of both rabies viral antigen and nucleic acid. The virus was shown to be most closely related to a vampire bat rabies isolate. These results indicate the importance of maintaining rabies in the differential diagnosis of acute febrile encephalitis, particularly in areas where exposure to vampire bats may occur.