Multiple Roles of Rab GTPases at the Golgi
Multiple Roles of Rab GTPases at the Golgi
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DOI：
10.1007/978-3-030-23173-6_6
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Progida, Cinzia
中科院分区：
文献类型：
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作者：
Progida, Cinzia
高尔基体是细胞中的中央分选站。它从内质网接收新合成的分子，并将它们引导到不同的亚细胞目的地，如质膜或内吞途径。重要的是，在过去的几年里，高尔基体结构的维持与膜运输的适当调节有关。RAB蛋白是一种小的GTP酶，被认为是细胞内膜运输的主要调节因子。60多个人类RAB中的几个参与了高尔基的运输路线的管理以及其建筑的维护。本章将总结Rab GTP酶在高尔基体中的不同作用，既作为膜运输、支架和系留蛋白的调节，也在保护这些细胞器的结构和功能方面。
The Golgi apparatus is a central sorting station in the cell. It receives newly synthesized molecules from the endoplasmic reticulum and directs them to different subcellular destinations, such as the plasma membrane or the endocytic pathway. Importantly, in the last few years, it has emerged that the maintenance of Golgi structure is connected to the proper regulation of membrane trafficking. Rab proteins are small GTPases that are considered to be the master regulators of the intracellular membrane trafficking. Several of the over 60 human Rabs are involved in the regulation of transport pathways at the Golgi as well as in the maintenance of its architecture. This chapter will summarize the different roles of Rab GTPases at the Golgi, both as regulators of membrane transport, scaffold, and tethering proteins and in preserving the structure and function of this organelle.