Chemically modified light-curable chitosans with enhanced potential for bone tissue repair.
Chemically modified light-curable chitosans with enhanced potential for bone tissue repair.
复制标题
化学改性的光固化壳聚糖具有增强骨组织修复潜力。
DOI：
10.1002/jbm.a.32017
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Wen,Xuejun
中科院分区：
文献类型：
--
作者：
Qiu,Yongzhi;Zhang,Ning;Kang,Qian;An,Yuehuei;Wen,Xuejun
光固化聚合物在克服目前骨修复中的一些障碍方面显示出巨大的潜力。通过立体光刻技术，它们可以被制成具有所需形貌的支架，用于修复不规则形状的骨缺损。在本研究中，我们开发了一系列光固化壳聚糖，其具有光固化性和在有机溶剂中良好的溶解性。通过调节原料组分的投料比例，可以控制壳聚糖主链中光固化基团的含量。通过FTIR-ATR和1H NMR对光固化壳聚糖进行了表征，这也证实了其可控光固化性。将 NIH 3T3 成纤维细胞与光固化样品共培养 7 天，结果表明这些光固化壳聚糖具有细胞相容性。使用盐浸和光固化制造具有互连孔的支架，并接种胎牛成骨细胞，将其皮下植入无胸腺大鼠的背部。 6周时植入物的组织学研究表明光固化壳聚糖具有良好的骨传导性。结果表明光固化壳聚糖具有良好的生物相容性和骨传导性。 © 2008 Wiley periodicals, Inc. J Biomed Mater Res，2009
Light curable polymers are showing great potential in overcoming some of the current obstacles in bone repair. With stereolithography, they can be fabricated into scaffolds with desired topography for repairing bone defects in irregular shapes. In this study, we developed a series of light curable chitosans, which have photocurability and good solubility in organic solvent. Through adjusting the feeding ratio of the raw components, the content of photocurable groups in the backbone of chitosan can be controlled. The light curable chitosans were characterized through FTIR–ATR and1H NMR, which also confirmed their controllable photocurability. NIH 3T3 fibroblasts were co‐cultured with the photocured samples for 7 days and the results indicated that these photocured chitosans are cyto‐compatible. Scaffolds with interconnected pores, fabricated using salt leaching and photocuring and seeded with fetal bovine osteoblasts, were implanted subcutaneously in the backs of athymic rat. Histological study on the implants at 6 weeks showed that the photocured chitosans have good osteoconductivity. The results indicated the light curable chitosans have good biocompatibility and osteoconductivity. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2009
影响因子：
37.8
作者：
AMBROSIO, G;BECKER, LC;WEISFELDT, ML
通讯作者：
WEISFELDT, ML