In-beam PET imaging for the control of heavy-ion tumour therapy
In-beam PET imaging for the control of heavy-ion tumour therapy
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DOI：
10.1109/23.632694
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发表时间：
1997-08-01
影响因子：
1.8
通讯作者：
Sobiella, M
中科院分区：
文献类型：
--
作者：
Pawelke, J;Enghardt, W;Sobiella, M
本文介绍了一种利用正电子发射断层扫描技术对重离子治疗肿瘤进行原位控制的方法。该方法建立在测量辐照过程中核碎裂产生的β（+）-发射体的动态空间分布及其与剂量的关系的基础上。为了研究这种关系并从测得的β（+）-放射性分布中推导出剂量分布，使用了模型计算框架。使用C-12离子束的体模实验结果将被呈现，证明实验和计算之间的良好一致性以及PET技术用于治疗计划验证和束流监测的可能性和限制。
A method for the in-situ control of the heavy-ion tumour therapy by means of positron emission tomography is introduced. This method is founded on the measurement of the dynamic spatial distributions of beta(+)-emitters generated by nuclear fragmentation during the irradiation and their relation to the dose. In order to study this relationship and to derive the dose distribution from the measured beta(+)-activity distribution, a framework of model calculations is used. Results of phantom experiments with C-12 ion beams will be presented, demonstrating good agreement between experiment and calculation as well as the possibilities and limits of the PET-technique for treatment plan verification and beam monitoring.