Synthesis of an MUC1 Glycopeptide Dendrimer Based on β-Cyclodextrin by Click Chemistry
Synthesis of an MUC1 Glycopeptide Dendrimer Based on β-Cyclodextrin by Click Chemistry
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通过点击化学合成基于 β-环糊精的 MUC1 糖肽树枝状聚合物
DOI：
10.1055/s-0036-1590796
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发表时间：
2017-09-01
期刊：
影响因子：
2
通讯作者：
Li, Yan-Mei
中科院分区：
文献类型：
--
作者：
Chen, Pu-Guang;Huang, Zhi-Hua;Li, Yan-Mei
糖肽树状聚合物是生物医学应用的有吸引力的候选者。本文介绍了一种基于β-环糊精的多价MUC 1糖肽树状大分子的制备方法。通过使用溴化铜（I）和茴香硫醚作为催化剂系统，精确定义的七价共轭物有效地获得。使用这种七价糖肽树状聚合物，我们观察到多价效应的识别和协会的过程中的抗体和表位的相互作用，这可能有生物医学应用。
Glycopeptide dendrimers are attractive candidates for biomedical applications. Here, an efficient method for preparing multivalent MUC1 glycopeptide dendrimers based on β-cyclodextrin is described. By using copper(I) bromide and thioanisole as a catalyst system, precisely defined heptavalent conjugates were efficiently obtained. Using this heptavalent glycopeptide dendrimer, we observed multivalent effects in recognition and association processes in antibody and epitope interactions, which might have biomedical applications.