Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice
Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice
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DOI：
10.1016/s0014-5793(96)01525-6
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发表时间：
1997-02-03
期刊：
影响因子：
3.5
通讯作者：
Hoggard, N
中科院分区：
文献类型：
--
作者：
Mercer, JG;Moar, KM;Hoggard, N
瘦素受体基因在下丘脑弓状核和腹内侧核中的表达已被测定。肥胖小鼠下丘脑两个区域的受体mRNA高于瘦鼠。连续7天每天2次给药瘦素深刻影响食物摄入量，降低弓形核中瘦素受体mRNA，并对神经肽Y基因表达产生类似影响。单次注射瘦素无效。瘦小鼠暴露于寒冷环境24小时，可诱导瘦素受体和NPY mRNA的表达，当动物返回温暖环境时，这种表达正常化。受体基因表达的调控可能是瘦素信号读取的重要组成部分。
Leptin receptor gene expression has been measured in arcuate and ventromedial hypothalamic nuclei. Receptor mRNA in both hypothalamic areas was higher in obese mice than in lean littermates. Twice daily leptin administration for 7 days profoundly affected food intake, reduced leptin receptor mRNA in the arcuate nucleus, and had a similar effect on neuropeptide Y gene expression. A single leptin injection was ineffective. Exposure of lean mice to cold for 24 h caused an induction of leptin receptor and NPY mRNA which was normalized when animals were returned to the warm. Regulation of receptor gene expression may be an important component in the reading of the leptin signal.