Effects of Photobiomodulation on Changes in Cognitive Function and Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment: A Pilot Uncontrolled Trial
Effects of Photobiomodulation on Changes in Cognitive Function and Regional Cerebral Blood Flow in Patients with Mild Cognitive Impairment: A Pilot Uncontrolled Trial
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DOI：
10.3233/jad-210386
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发表时间：
2021-01-01
影响因子：
4
通讯作者：
Shin, Yong-Il
中科院分区：
文献类型：
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作者：
Baik, Ji Soo;Lee, Tae Young;Shin, Yong-Il
背景：光生物调节（PBM）通过一氧化氮的产生影响局部血流调节，各种研究报道了其对改善神经退行性疾病认知功能的作用。然而，之前尚未研究过 PBM 对大脑主要供血动脉椎动脉 (VA) 和颈内动脉 (ICA) 区域的影响。 目的：我们的目的是确定在大脑主要供血动脉 VA 和 ICA 区域照射 PBM 是否可以改善局部脑血流量 (rCBF) 和认知功能。 方法：14 名患者患有轻度认知障碍的患者接受 PBM 治疗。在基线和 PBM 结束时进行认知评估和单光子发射计算机断层扫描。结果：关于 rCBF，在内侧前额叶皮层、外侧前额叶皮层、前扣带皮层和枕外侧皮层中发现了统计学上显着的趋势。根据认知评估，在整体认知功能、记忆力和额叶/执行功能方面发现了统计上显着的趋势。结论：我们证实了 VA 和 ICA 区域的 PBM 治疗可以通过增加 rCBF 对认知功能产生积极影响。需要进行更大样本量的研究来验证 PBM 的潜力。
Background: Photobiomodulation (PBM) affects local blood flow regulation through nitric oxide generation, and various studies have reported on its effect on improving cognitive function in neurodegenerative diseases. However, the effect of PBM in the areas of the vertebral arteries (VA) and internal carotid arteries (ICA), which are the major blood-supplying arteries to the brain, has not been previously investigated.Objective: We aimed to determine whether irradiating PBM in the areas of the VA and ICA, which are the major blood-supplying arteries to the brain, improved regional cerebral blood flow (rCBF) and cognitive function.Methods: Fourteen patients with mild cognitive impairments were treated with PBM. Cognitive assessment and single-photon emission computed tomography were implemented at the baseline and at the end of PBM.Results: Regarding rCBF, statistically significant trends were found in the medial prefrontal cortex, lateral prefrontal cortex, anterior cingulate cortex, and occipital lateral cortex. Based on the cognitive assessments, statistically significant trends were found in overall cognitive function, memory, and frontal/executive function.Conclusion: We confirmed the possibility that PBM treatment in the VA and ICA areas could positively affect cognitive function by increasing rCBF. A study with a larger sample size is needed to validate the potential of PBM.